Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb:160:107988.
doi: 10.1016/j.diabres.2019.107988. Epub 2019 Dec 19.

Association between sleep disturbances, fear of hypoglycemia and psychological well-being in adults with type 1 diabetes mellitus, data from cross-sectional VARDIA study

Valentine Suteau  1 , Pierre-Jean Saulnier  2 , Matthieu Wargny  3 , Linda Gonder-Frederick  4 , Elise Gand  5 , Lucy Chaillous  6 , Ingrid Allix  7 , Séverine Dubois  8 , Fabrice Bonnet  9 , Anne-Marie Leguerrier  10 , Gerard Fradet  11 , Ingrid Delcourt Crespin  12 , Véronique Kerlan  13 , Didier Gouet  14 , Caroline Perlemoine  15 , Pierre-Henri Ducluzeau  16 , Matthieu Pichelin  17 , Stéphanie Ragot  18 , Samy Hadjadj  19 , Bertrand Cariou  20 , Claire Briet  21 ; VARDIA study group
Affiliations

Association between sleep disturbances, fear of hypoglycemia and psychological well-being in adults with type 1 diabetes mellitus, data from cross-sectional VARDIA study

Valentine Suteau et al. Diabetes Res Clin Pract. 2020 Feb.

Abstract

Aim: To assess the relationship between sleep quality, fear of hypoglycemia, glycemic variability and psychological well-being in type 1 diabetes mellitus.

Methods: Our data were provided by the VARDIA Study, a multicentric cross-sectional study conducted between June and December 2015. Sleep characteristics were assessed by the Pittsburgh Sleep Quality Index (PSQI). Fear of hypoglycemia and psychological well-being were measured with the Hypoglycemia Fear Survey version II (HFS-II) and the Hospital Anxiety and Depression Scale (HADS), respectively. Glycemic variability (GV) was determined using the CV of three 7-point self-monitoring blood glucose profiles and the mean amplitude of glycemic excursion (MAGE).

Results: 315 patients were eligible for PSQI questionnaire analysis: 54% women, mean age 47 ± 15, mean diabetes duration of 24 ± 13 years, HbA1c of 7.6 ± 0.9% (60 ± 7,5mmol/mol). Average PSQI score was 6.0 ± 3.3 and 59.8% of the patients had a PSQI score > 5. HFS-II score and HADS were significantly higher among "poor" sleepers (p < 0.0001) and PSQI score was positively associated with HADS (β = 0.22; 95% CI = 0.08;0.35). GV evaluated by CV or MAGE did not differ between "poor" and "good" sleepers (p = 0.28 and 0.54, respectively).

Conclusions: Adult patients with type 1 diabetes have sleep disturbances which correlate with psychological well-being. This study suggests that psychological management can be a target to improve sleep quality in adults with type 1 diabetes mellitus.

Keywords: Anxiety-Depression; Fear of hypoglycaemia; Glycemic variability; Sleep disturbances; Type 1 diabetes mellitus.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The HFS-II is copyrighted and licensed through the University of Virginia. Licencing fees are used to support Dr. Gonder-Frederick's research on fear of hypoglycemia and related topics. S.H reports grants from ADAIRC and Dinno Santé, during the conduct of the study; personal fees and non-financial support from Astra Zeneca, personal fees and other from Bayer, Boehringer Ingelheim, Merck Sharpe Dome, Novonordisk, Sanofi, Servier and Eli Lilly, personal fees from Abbott DIAGNOSTICS, grants from Pierre Fabre Santé, outside the submitted work. B.C reports grants from Novo Nordsik, during the conduct of the study; personal fees from Abbott, Akcea, BMS, Genfi, Pierre Fabreand MSD, grants and personal fees from Amgen, Novo Nordsik, Regeneron and Sanofi, outside the submitted work.

LinkOut - more resources