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Editorial
. 2019 Dec 6:10:851.
doi: 10.3389/fendo.2019.00851. eCollection 2019.

Editorial: Metformin: Beyond Diabetes

Affiliations
Editorial

Editorial: Metformin: Beyond Diabetes

Frédéric Bost et al. Front Endocrinol (Lausanne). .
No abstract available

Keywords: PCOS (polycystic ovarian syndrome); cancer; diabetes; gut microbiota; metformin; mitochondria; neurodegenerative disease.

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  • Editorial on the Research Topic Metformin: Beyond Diabetes

References

    1. El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. (2000) 275:223–8. 10.1074/jbc.275.1.223 - DOI - PubMed
    1. Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. (2000) 348(Pt 3), 607–614. 10.1042/bj3480607 - DOI - PMC - PubMed
    1. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. . Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. (2001) 108:1167–74. 10.1172/JCI13505 - DOI - PMC - PubMed
    1. Foretz M, Guigas B, Viollet B. Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus. Nat Rev Endocrinol. (2019) 15:569–89. 10.1038/s41574-019-0242-2 - DOI - PubMed
    1. Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, et al. . Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. (2010) 120:2355–69. 10.1172/JCI40671 - DOI - PMC - PubMed

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