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Review
. 2019 Dec;53(6):374-381.
doi: 10.1007/s13139-019-00618-6. Epub 2019 Nov 12.

Radioimmunotherapy (RIT) in Brain Tumors

Ali Gholamrezanezhad  1 , Hossein Shooli  2 , Narges Jokar  2 , Reza Nemati  3 , Majid Assadi  2
Affiliations
Review

Radioimmunotherapy (RIT) in Brain Tumors

Ali Gholamrezanezhad et al. Nucl Med Mol Imaging. 2019 Dec.

Abstract

Annually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as a critical aim of treatment. One of these new challenging methods is radioimmunotherapy (RIT) that involves recruiting a coupling of radionuclide component with monoclonal antibody (mAb) which are targeted against cell surface tumor-related antigens or antigens of cells within the tumor microenvironment. In the context of cancer care, precision medicine is exemplified by RIT; precision medicine can offer a tailored treatment to meet the needs for treatment of brain tumors. This review aims to discuss the molecular targets used in radioimmunotherapy of brain tumors, available and future radioimmunopharmaceutics, clinical trials of radioimmunotherapy in brain neoplasms, and eventually, conclusion and future perspective of application of radioimmunotherapy in neurooncology cancer care.

Keywords: Brain tumors; Monoclonal antibody (mAb); Radioimmunotherapy (RIT).

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Conflict of interest statement

Conflict of InterestAli Gholamrezanezhad, Hossein Shooli, Narges Jokar, Reza Nemati, and Majid Assadi declare that they have no conflict of interest.

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