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Review
. 2019 Nov;9(6):1145-1162.
doi: 10.1016/j.apsb.2019.08.003. Epub 2019 Aug 19.

Recent progress in drug delivery

Chong Li  1 , Jiancheng Wang  2 , Yiguang Wang  2 , Huile Gao  3 , Gang Wei  4 , Yongzhuo Huang  5 , Haijun Yu  5 , Yong Gan  5 , Yongjun Wang  6 , Lin Mei  7 , Huabing Chen  8 , Haiyan Hu  9 , Zhiping Zhang  10 , Yiguang Jin  11
Affiliations
Review

Recent progress in drug delivery

Chong Li et al. Acta Pharm Sin B. 2019 Nov.

Abstract

Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015-2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.

Keywords: Application; Basic research; Delivery strategy; Drug delivery system; Pharmaceutics.

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Figures

Image 1
Graphical abstract
Figure 1
Figure 1
The schematic diagram of pH-triggered morphological transformation from self-assembled nanoparticles (NPs) to nanofibers (NFs) and a pre-nested host in a tumor where thermally sensitive drugs are located (Adapted from Ref.  with permission. Copyright © 2017 Wiley).
Figure 2
Figure 2
(A) The nanoparticle-based combination therapy. (B) Plasma drug concentrations after i.v. injection of the VYXEOS® liposomes and the free combo drugs in mice (Adapted from Ref.  with permission. Copyright © 2016, Elsevier and Ref.  with permission. Copyright © 2019, American Association for Cancer).
Figure 3
Figure 3
Schematic diagram of pH-tunable sticky vesicles, conventional uniformly functionalized nanoparticle with or without tether (PEG), and their affinity towards target cells with different receptor expressions.
Figure 4
Figure 4
Formation and advantages of prodrug nanomedicines (PNs).
Figure 5
Figure 5
a) The dynamic interaction between DOX and benzaldehyde via pH-sensitive benzoic–imine bond. b) Schematic illustration of the drug DOX self-gated MSNs with pH-responsive drug release property. c) Dynamically PEGylated and DOX self-gated MSNs with site-specific drug release at weak acidic tumor tissue/cells.
See this image and copyright information in PMC

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