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. 2019 Nov 27:13:100188.
doi: 10.1016/j.lrr.2019.100188. eCollection 2020.

Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Darlen Cardoso Carvalho  1 , Alayde Vieira Wanderley  1   2 , Fernando Augusto Rodrigues Mello Junior  1 , André Mauricio Ribeiro Dos Santos  3 , Luciana Pereira Colares Leitão  1 , Tatiane Piedade de Souza  1 , Amanda de Nazaré Cohen Lima de Castro  1 , Leandro Lopes de Magalhães  3 , Marianne Rodrigues Fernandes  1 , João Augusto Nunes de Carvalho Junior  1 , André Salim Khayat  1 , Sidney Santos  1   3 , Paulo Pimentel de Assumpção  1   4 , Ney Pereira Carneiro Dos Santos  1   3
Affiliations

Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Darlen Cardoso Carvalho et al. Leuk Res Rep. .

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.

Keywords: ALL; Admixed; Pediatrics; Polymorphisms; Susceptibility.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Box plot graph elucidates the difference between case and control groups for Amerindian, African and European ancestries in the study population.
Fig. 2
Fig. 2
Odds ratio of the polymorphisms investigated between case and control groups. The plot illustrates the polymorphisms odds-ratio and their 95% confidence interval by the point and line ranges, the null effect (OR = 1) is indicated by the vertical dotted line and the genetic effect model is indicated by the colors red, green and blue for dominant, log-additive and recessive models, respectively.
Fig. 3
Fig. 3
Distribution of ARID5B_ rs10821936 gene variants according to B-ALL leukemia subtype.
Fig. 4
Fig. 4
Distribution of CEBPE_ rs2239633 gene variants according to B-ALL leukemia subtype.
Fig. 1S
Fig. 1S
Distribution of cytogenetic subtypes of B-ALL for the patients investigated.
See this image and copyright information in PMC

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