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Review
. 2019 Dec 5:7:398.
doi: 10.3389/fbioe.2019.00398. eCollection 2019.

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Yuanyuan Tian  1   2 , Sheng Qiang  1 , Lianhui Wang  2
Affiliations
Review

Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Yuanyuan Tian et al. Front Bioeng Biotechnol. .

Abstract

In recent years, tremendous efforts have been devoted into the fields of valuable diagnosis and anticancer treatment, such as real-time imaging, photothermal, and photodynamic therapy, and drug delivery. As promising nanocarriers, gold nanomaterials have attracted widespread attention during the last two decades for cancer diagnosis and therapy due to their prominent properties. With the development of nanoscience and nanotechnology, the fascinating bio-applications of functionalized gold nanomaterials have been gradually developed from in vitro to in vivo. This mini-review emphasizes some recent advances of photothermal imaging (PTI), surface-enhanced Raman scattering (SERS) imaging, and photoacoustic imaging (PAI)-guided based on gold nanomaterials in vivo therapy in near infrared region (>800 nm). We focus on the fundamental strategies, characteristics of bio-imaging modalities involving the advantages of multiples imaging modalities for cancer treatment, and then highlight a few examples of each techniques. Finally, we discuss the perspectives and challenges in gold nanomaterial-based cancer therapy.

Keywords: gold nanomaterials; in vivo; photoacoustic imaging; photothermal therapy; surface-enhanced Raman scattering.

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Figures

Figure 1
Figure 1
Illustration of multifunctional NIR gold nanomaterials platform for three imaging modalities.
See this image and copyright information in PMC

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