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Case Reports
. 2019 Nov 21:21:1-4.
doi: 10.1016/j.ctro.2019.11.001. eCollection 2020 Mar.

Successful treatment of primary cutaneous angiosarcoma of the nose with sequential chemo- and radiotherapy

H Herrscher  1 , M Bronnec  2 , D Antoni  3   4 , J-P Ghnassia  5 , P Magnenet  2 , J-E Kurtz  1 , G Noël  3   4
Affiliations
Case Reports

Successful treatment of primary cutaneous angiosarcoma of the nose with sequential chemo- and radiotherapy

H Herrscher et al. Clin Transl Radiat Oncol. .

Abstract

•The optimal treatment of primary cutaneous angiosarcoma is considered to be surgical exision.•Concurrent chemo-radiotherapy is efficient in the treatment of primary cutaneous angiosarcoma.•The toxicity profile of this association is acceptable.

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Figures

Fig. 1
Fig. 1
Initial presentation of the tumor A-Clinical aspect of the angiosarcoma B-MRI T1 sequence aspect of the angiosarcoma before treatment.
Fig. 2
Fig. 2
Histological characteristics of the angiosarcoma 2A: hematoxylin-eosin: atypical endothelial cells involving the dermis and surrounding atypical vascular spaces 2B: sarcomatous proliferation: atypical epithelioid cells 2C: immunohistochemistry: CD31 membranous expression of tumor cells 2D: immunohistochemistry: ERG nuclear expression of tumor cell.
Fig. 3
Fig. 3
Clinical complete response after neo-adjuvant chemotherapy.
Fig. 4
Fig. 4
Irradiation planification and dose distribution Purple margins: GTV Yellow line: CTV Brown line: PTV Red area: 57 Gy isodose Orange area: 54 Gy isodose Blue area: 20 Gy isodose Green area: 15 Gy isodose. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 5
Fig. 5
MRI T1 sequence aspect of the angiosarcoma after treatment.
Fig. 6
Fig. 6
Clinical aspect two years after the treatment.
See this image and copyright information in PMC

References

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