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Book

Thiazolidinediones

Julie S. Eggleton  1 , Ishwarlal Jialal  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Thiazolidinediones

Julie S. Eggleton et al.
Free Books & Documents

Excerpt

Thiazolidinediones are medications used to manage and treat type 2 diabetes mellitus. These medications may act as a nuclear transcription regulator and an insulin sensitizer. This activity illustrates the indications, mechanism of action, and contraindications for thiazolidinediones as valuable agents for managing type 2 diabetes.

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Conflict of interest statement

Disclosure: Julie Eggleton declares no relevant financial relationships with ineligible companies.

Disclosure: Ishwarlal Jialal declares no relevant financial relationships with ineligible companies.

References

    1. Yau H, Rivera K, Lomonaco R, Cusi K. The future of thiazolidinedione therapy in the management of type 2 diabetes mellitus. Curr Diab Rep. 2013 Jun;13(3):329-41. - PubMed
    1. Musso G, Cassader M, Paschetta E, Gambino R. Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis: A Meta-analysis. JAMA Intern Med. 2017 May 01;177(5):633-640. - PMC - PubMed
    1. He L, Liu X, Wang L, Yang Z. Thiazolidinediones for nonalcoholic steatohepatitis: A meta-analysis of randomized clinical trials. Medicine (Baltimore) 2016 Oct;95(42):e4947. - PMC - PubMed
    1. Yamanouchi T. Concomitant therapy with pioglitazone and insulin for the treatment of type 2 diabetes. Vasc Health Risk Manag. 2010 Apr 15;6:189-97. - PMC - PubMed
    1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet] National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda (MD): 2017. Jun 6, Antidiabetic Agents. - PubMed

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