A highly potent trimeric derivative of artesunate shows promising treatment profiles in experimental models for congenital HCMV infection in vitro and ex vivo

Affiliations

¹ Université Limoges, UMR1092, 2 rue du Pr Descottes, 87000, Limoges, France; INSERM, UMR 1092, 2 rue du Pr Descottes, 87000, Limoges, France.
² Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg, Schlossgarten 4, 91054, Erlangen, Germany.
³ Université Limoges, UMR1092, 2 rue du Pr Descottes, 87000, Limoges, France; INSERM, UMR 1092, 2 rue du Pr Descottes, 87000, Limoges, France; National Reference Center for Herpesviruses, Virology department, CHU Limoges, 2 rue Martin Luther King, 87000, Limoges, France.
⁴ Mother and Child Biobank (CB-HME), Pediatric department, Hôpital de la mère et de l'enfant, CHU Limoges, Limoges, France.
⁵ Department of Biochemistry and molecular Genetics, CHU Limoges, France.
⁶ Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
⁷ Université Limoges, UMR1092, 2 rue du Pr Descottes, 87000, Limoges, France; INSERM, UMR 1092, 2 rue du Pr Descottes, 87000, Limoges, France; National Reference Center for Herpesviruses, Virology department, CHU Limoges, 2 rue Martin Luther King, 87000, Limoges, France. Electronic address: sophie.alain@unilim.fr.

Chloé Jacquet et al. Antiviral Res. 2020 Mar.

. 2020 Mar:175:104700.

doi: 10.1016/j.antiviral.2019.104700. Epub 2019 Dec 20.

¹ Université Limoges, UMR1092, 2 rue du Pr Descottes, 87000, Limoges, France; INSERM, UMR 1092, 2 rue du Pr Descottes, 87000, Limoges, France.
² Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg, Schlossgarten 4, 91054, Erlangen, Germany.
³ Université Limoges, UMR1092, 2 rue du Pr Descottes, 87000, Limoges, France; INSERM, UMR 1092, 2 rue du Pr Descottes, 87000, Limoges, France; National Reference Center for Herpesviruses, Virology department, CHU Limoges, 2 rue Martin Luther King, 87000, Limoges, France.
⁴ Mother and Child Biobank (CB-HME), Pediatric department, Hôpital de la mère et de l'enfant, CHU Limoges, Limoges, France.
⁵ Department of Biochemistry and molecular Genetics, CHU Limoges, France.
⁶ Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
⁷ Université Limoges, UMR1092, 2 rue du Pr Descottes, 87000, Limoges, France; INSERM, UMR 1092, 2 rue du Pr Descottes, 87000, Limoges, France; National Reference Center for Herpesviruses, Virology department, CHU Limoges, 2 rue Martin Luther King, 87000, Limoges, France. Electronic address: sophie.alain@unilim.fr.

No abstract available

Conflict of interest statement

Declaration of competing interest None.