Perspectives in allergen immunotherapy: 2019 and beyond

Oliver Pfaar¹, Ioana Agache², Frédéric de Blay³, Sergio Bonini⁴, Adam M Chaker⁵, Stephen R Durham^{6

7}, Radoslaw Gawlik⁸, Peter W Hellings^{9

10

11}, Marek Jutel^{12

13}, Jörg Kleine-Tebbe¹⁴, Ludger Klimek¹⁵, Matthias V Kopp^{16

17}, Andreas Nandy¹⁸, Ronald L Rabin¹⁹, Ronald van Ree²⁰, Harald Renz²¹, Graham Roberts^{22

23}, Anne-Marie Salapatek²⁴, Carsten B Schmidt-Weber^{25

26}, Mohamed H Shamji^{6

7}, Gunter J Sturm^{27

28}, J Christian Virchow²⁹, Ulrich Wahn³⁰, Christoph Willers¹⁸, Petra Zieglmayer³¹, Cezmi A Akdis^{32

33}

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
² Faculty of Medicine, Transylvania University, Brasov, Romania.
³ Pneumology Department, New Civil Hospital, Strasbourg-Cedex, France.
⁴ Institute of Translational Medicine, Italian National Research Council, Rome, Italy.
⁵ Department of Otolaryngology and Center of Allergy and Environment, TUM School of Medicine, Technical University of Munich, Munich, Germany.
⁶ Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK.
⁷ MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
⁸ Department of Internal Medicine, Allergology and Clinical Immunology, Silesian University of Medicine, Katowice, Poland.
⁹ Department of Otorhinolaryngology, University Hospitals of Leuven, Leuven, Belgium.
¹⁰ Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
¹¹ Department of Neuroscience, University of Ghent, Ghent, Belgium.
¹² Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland.
¹³ All-Med Medical Research Institute, Wroclaw, Poland.
¹⁴ Allergy & Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Berlin, Germany.
¹⁵ Center for Rhinology and Allergology, Wiesbaden, Germany.
¹⁶ Department of Pediatric Allergy and Pulmonology, University of Luebeck, Luebeck, Germany.
¹⁷ Member of the Deutsches Zentrum für Lungenforschung (DZL), Airway Research Center North (ARCN), Luebeck, Germany.
¹⁸ Research & Development, Allergopharma GmbH & Co. KG, Reinbek, Germany.
¹⁹ Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
²⁰ Departments of Experimental Immunology and of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
²¹ Department Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Giessen and Philipps-Universität Marburg, Marburg, Germany.
²² Paediatric Allergy and Respiratory Medicine, University of Southampton, Southampton, UK.
²³ David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK.
²⁴ Inflamax Research DBA Cliantha Research, Mississauga, ON, Canada.
²⁵ Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany.
²⁶ Member of the German Center for Lung Research (DZL), Lübeck, Germany.
²⁷ Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
²⁸ Allergy Outpatient Clinic Reumannplatz, Vienna, Austria.
²⁹ Department Pulmonology & Interdisciplinary Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.
³⁰ Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
³¹ Vienna Challenge Chamber, Vienna, Austria.
³² Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland.
³³ Christine-Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.

PMID: 31872476
DOI: 10.1111/all.14077

Review

Perspectives in allergen immunotherapy: 2019 and beyond

Oliver Pfaar et al. Allergy. 2019 Dec.

. 2019 Dec:74 Suppl 108:3-25.

doi: 10.1111/all.14077.

Authors

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
² Faculty of Medicine, Transylvania University, Brasov, Romania.
³ Pneumology Department, New Civil Hospital, Strasbourg-Cedex, France.
⁴ Institute of Translational Medicine, Italian National Research Council, Rome, Italy.
⁵ Department of Otolaryngology and Center of Allergy and Environment, TUM School of Medicine, Technical University of Munich, Munich, Germany.
⁶ Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK.
⁷ MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
⁸ Department of Internal Medicine, Allergology and Clinical Immunology, Silesian University of Medicine, Katowice, Poland.
⁹ Department of Otorhinolaryngology, University Hospitals of Leuven, Leuven, Belgium.
¹⁰ Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
¹¹ Department of Neuroscience, University of Ghent, Ghent, Belgium.
¹² Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland.
¹³ All-Med Medical Research Institute, Wroclaw, Poland.
¹⁴ Allergy & Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Berlin, Germany.
¹⁵ Center for Rhinology and Allergology, Wiesbaden, Germany.
¹⁶ Department of Pediatric Allergy and Pulmonology, University of Luebeck, Luebeck, Germany.
¹⁷ Member of the Deutsches Zentrum für Lungenforschung (DZL), Airway Research Center North (ARCN), Luebeck, Germany.
¹⁸ Research & Development, Allergopharma GmbH & Co. KG, Reinbek, Germany.
¹⁹ Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
²⁰ Departments of Experimental Immunology and of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
²¹ Department Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Giessen and Philipps-Universität Marburg, Marburg, Germany.
²² Paediatric Allergy and Respiratory Medicine, University of Southampton, Southampton, UK.
²³ David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK.
²⁴ Inflamax Research DBA Cliantha Research, Mississauga, ON, Canada.
²⁵ Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany.
²⁶ Member of the German Center for Lung Research (DZL), Lübeck, Germany.
²⁷ Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
²⁸ Allergy Outpatient Clinic Reumannplatz, Vienna, Austria.
²⁹ Department Pulmonology & Interdisciplinary Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.
³⁰ Department for Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
³¹ Vienna Challenge Chamber, Vienna, Austria.
³² Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland.
³³ Christine-Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.

PMID: 31872476
DOI: 10.1111/all.14077

Abstract

The seventh "Future of the Allergists and Specific Immunotherapy (FASIT)" workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following: (a) Biomarkers for AIT and allergic asthma; (b) visions for the future of AIT; (c) progress and data for AIT in asthma and the updates of GINA and EAACI Asthma Guidelines (separated for house dust mite SCIT, SLIT tablets and SLIT drops; patient populations) including a review of clinically relevant endpoints in AIT studies in asthma; (d) regulatory prerequisites such as the "Therapy Allergen Ordinance" in Germany; (e) optimization of trial design in AIT clinical research; (f) challenges planning and conducting phase III (field) studies and the future role of Allergen Exposure Chambers (AEC) in AIT product development from the regulatory point of view. We report a summary of panel discussions of all six domains and highlight unmet needs and possible solutions for the future.

Keywords: allergen exposure chamber; allergen immunotherapy; allergic asthma; biomarker; clinical trials.

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References

REFERENCES

1. Agache I, Akdis CA, Chivato T, et al. EAACI White Paper on Research, Innovation and Quality Care; 2018. www.eaaci.org Accessed April 1, 2019
1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2018. www.ginasthma.com.
1. Dhami S, Nurmatov U, Arasi S, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis. Allergy. 2017;72(11):1597-1631.
1. Dhami S, Kakourou A, Asamoah F, et al. Allergen immunotherapy for allergic asthma: a systematic review and meta-analysis. Allergy. 2017;72(12):1825-1848.
1. Dhami S, Zaman H, Varga EM, et al. Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis. Allergy. 2017;72(3):342-365.

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Perspectives in allergen immunotherapy: 2019 and beyond

Affiliations

Perspectives in allergen immunotherapy: 2019 and beyond

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical