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. 2021 Nov;35(22):4685-4689.
doi: 10.1080/14786419.2019.1705818. Epub 2019 Dec 24.

Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells

Dang Viet Hau  1 , Nguyen Hoang Sa  2   3 , Nguyen Thanh Tam  1   2 , Nguyen Thi Diep  2 , Nguyen Thi Hoang Anh  1   2 , Nguyen Thi Thuy Linh  1   2 , Huynh Thi Ngoc Ni  4 , Sabrina Adorisio  5 , Domenico V Delfino  5   6 , Trinh Thi Thuy  1   2
Affiliations

Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells

Dang Viet Hau et al. Nat Prod Res. 2021 Nov.

Abstract

Previously, we isolated four known diterpenoids, trans-communic acid (1), 13-oxo-15,16-dinor-labda-8(17), 11E-diene-19-oic acid (2), 3β-hydroxytotarol (3), and totarolone (4) from Fokienia hodginsii leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3β-hydroxytotarol (3) had very powerful bioactivity at low concentrations (5 µg/mL).

Keywords: 3β-hydroxytotarol; Fokienia hodginsii; OCI-AML cells; antiproliferative activity; cancer; diterpene.

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