Medial temporal lobe white matter pathway variability is associated with individual differences in episodic memory in cognitively normal older adults

Abstract

Significant evidence demonstrates that aging is associated with variability in cognitive performance, even among individuals who are cognitively normal. In this study, we examined measures from magnetic resonance imaging and cerebrospinal fluid (CSF) to investigate which measures, alone or in combination, were associated with individual differences in episodic memory performance. Using hierarchical linear regressions, we compared the ability of diffusion tensor imaging (DTI) metrics, CSF measures of amyloid and tau, and gray matter volumes to explain variability in memory performance in a cohort of cognitively normal older adults. Measures of DTI microstructure were significantly associated with variance in memory performance, even after accounting for the contribution of the CSF and magnetic resonance imaging gray matter volume measures. Significant associations were found between DTI measures of the hippocampal cingulum and fornix with individual differences in memory. No such relationships were found between memory performance and CSF markers or gray matter volumes. These findings suggest that DTI metrics may be useful in identifying changes associated with aging or age-related diseases.

Keywords: Biomarker; Cerebrospinal fluid; Cognitive aging; Diffusion tensor imaging; Episodic memory.

Figure 1.. Delayed memory performance associations with white matter microstructure.

Partial regression plots with standardized residuals depicting the relationship of delayed episodic memory performance with fornix and hippocampal cingulum microstructure from the final step of the hierarchical regression model using mean diffusivity (MD) as the primary DTI metric of interest (a) and the final step of the hierarchical regression model using radial diffusivity (RD) as the primary DTI metric of interest (b).