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Meta-Analysis
. 2019 Dec;98(52):e18353.
doi: 10.1097/MD.0000000000018353.

The effect of text message reminders on medication adherence among patients with coronary heart disease: A systematic review and meta-analysis

Ya-Yun Zhao  1 , Fang-Ping Dang  2 , Tian-Tian Zhai  2 , Hui-Ju Li  2 , Rui-Juan Wang  2 , Jing-Jie Ren  2
Affiliations
Meta-Analysis

The effect of text message reminders on medication adherence among patients with coronary heart disease: A systematic review and meta-analysis

Ya-Yun Zhao et al. Medicine (Baltimore). 2019 Dec.

Abstract

Background: To determine the effectiveness of text message reminders (TMR) on medication adherence (MA) and to investigate the effects of TMR on clinical outcomes.

Methods: The PubMed, Cochrane library, EMbase, and China Biology Medicine databases were searched for randomized-controlled trials with TMR as the intervention for patients with coronary heart disease. Two reviewers independently extracted data and assessed the risk of bias. Meta-analysis was conducted using Stata 15.0 software.

Results: In total, 1678 patients in 6 trials were included. Compared with the control group, the MA was 2.85 times greater among the intervention group (RR [relative risk] 2.85; 95% confidence interval [CI] 1.07-7.58). TMR reduced systolic blood pressure (BP) (weighted mean difference) = -6.51; 95% CI -9.79 to -3.23), cholesterol (standard mean difference = -0.26; 95% CI -0.4 to -0.12) and increased the number of patients with BP <140/90 mm Hg (RR 1.39; 95% CI 1.26-1.54).

Conclusion: TMR significantly promoted MA and reduced systolic BP, cholesterol level, and body mass index, but had no effect on mortality, diastolic BP, or lipoproteins. However, substantial heterogeneity existed in our analyses.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
The evaluation result of the included studies. The words on the left represent the content of the evaluation, and the long strips on the right represents the evaluation result, where red indicates high bias, and green indicates low bias and yellow indicates unclear bias.
Figure 2
Figure 2
The selection process of included studies. The pointing of the arrow indicates the steps of filtering.
Figure 3
Figure 3
The result of meta-analysis showed that text message reminder significantly improved medication adherence, which did not intersect with X = 1. Red lines represent the total amount of effect. Black lines represent the amount of effect in the 2 studies respectively.
See this image and copyright information in PMC

References

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