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. 2020 Aug 7;41(30):2904-2907.
doi: 10.1093/eurheartj/ehz907.

Somatic mosaicism: implications for the cardiovascular system

Affiliations

Somatic mosaicism: implications for the cardiovascular system

Soichi Sano et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
We are mosaics. Recent studies have documented somatic mosaicism and aberrant clonal expansions in multiple cell types and tissues.

References

    1. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D’Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA.. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science 2015;350:94–98. - PMC - PubMed
    1. Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA.. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science 2018;359:555–559. - PMC - PubMed
    1. Martincorena I, Roshan A, Gerstung M, Ellis P, Loo PV, McLaren S, Wedge DC, Fullam A, Alexandrov LB, Tubio JM, Stebbings L, Menzies A, Widaa S, Stratton MR, Jones PH, Campbell PJ.. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 2015;348:880–886. - PMC - PubMed
    1. Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall M, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH.. Somatic mutant clones colonize the human esophagus with age. Science 2018;362:911–917. - PMC - PubMed
    1. Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, Shiozawa Y, Sato Y, Aoki K, Kim SK, Fujii Y, Yoshida K, Kataoka K, Nakagawa MM, Inoue Y, Hirano T, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Nishikawa Y, Amanuma Y, Ohashi S, Aoyama I, Horimatsu T, Miyamoto S, Tsunoda S, Sakai Y, Narahara M, Brown JB, Sato Y, Sawada G, Mimori K, Minamiguchi S, Haga H, Seno H, Miyano S, Makishima H, Muto M, Ogawa S.. Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature 2019;565:312–317. - PubMed

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