Endoplasmic reticulum stress in autoimmune diseases

Abstract

If the body's immune system is disordered and begins to attack "self" and therefore, its own tissues this is considered to be an autoimmune pathology. The specific mechanisms vary between the different diseases and have not always been elucidated but chronic, non-resolving inflammation is a common theme in the pathogenesis of autoimmune diseases. Interestingly, it has been shown that development and occurrence of various inflammatory responses are closely correlated to endoplasmic reticulum stress. Therefore, this review discusses the current progress of research about the relationship between autoimmune diseases and endoplasmic reticulum stress, specifically the unfolded protein response (UPR).

Keywords: Ankylosing spondylitis; Endoplasmic reticulum stress; Inflammatory bowel disease; Rheumatoid arthritis; Sjögren's syndrome; Systemic lupus erythematosus.