Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019

doi:10.1016/j.ijporl.2019.109838

Review

. 2020 Mar:130 Suppl 1:109838.

doi: 10.1016/j.ijporl.2019.109838. Epub 2019 Dec 19.

Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019

R B Thornton¹, A Hakansson², D W Hood³, J Nokso-Koivisto⁴, D Preciado⁵, K Riesbeck⁶, P C Richmond⁷, Y C Su⁶, W E Swords⁸, K L Brockman⁹

Affiliations

¹ Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia; School of Biomedical Sciences, Faculty Health and Medical Science, University of Western Australia, Perth, Western Australia, Australia.
² Experimental Infection Medicine, Dept. of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
³ MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, OX11 0RD, UK.
⁴ Department of Otorhinolaryngology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁵ Sheikh Zayed Center for Pediatric Surgical Innovation, Children's National Health System, Washington, DC, USA; Division of Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA.
⁶ Clinical Microbiology, Dept. of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
⁷ School of Medicine, Division of Paediatrics, Faculty Health and Medical Science, University of Western Australia, Perth, Western Australia, Australia; Perth Children's Hospital, Perth, Western Australia, Australia.
⁸ Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁹ Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: kbrockman@mcw.edu.

PMID: 31879085
PMCID: PMC7062565
DOI: 10.1016/j.ijporl.2019.109838

Review

Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019

R B Thornton et al. Int J Pediatr Otorhinolaryngol. 2020 Mar.

. 2020 Mar:130 Suppl 1:109838.

doi: 10.1016/j.ijporl.2019.109838. Epub 2019 Dec 19.

Authors

R B Thornton¹, A Hakansson², D W Hood³, J Nokso-Koivisto⁴, D Preciado⁵, K Riesbeck⁶, P C Richmond⁷, Y C Su⁶, W E Swords⁸, K L Brockman⁹

Affiliations

¹ Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia; School of Biomedical Sciences, Faculty Health and Medical Science, University of Western Australia, Perth, Western Australia, Australia.
² Experimental Infection Medicine, Dept. of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
³ MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, OX11 0RD, UK.
⁴ Department of Otorhinolaryngology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁵ Sheikh Zayed Center for Pediatric Surgical Innovation, Children's National Health System, Washington, DC, USA; Division of Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA.
⁶ Clinical Microbiology, Dept. of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.
⁷ School of Medicine, Division of Paediatrics, Faculty Health and Medical Science, University of Western Australia, Perth, Western Australia, Australia; Perth Children's Hospital, Perth, Western Australia, Australia.
⁸ Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
⁹ Department of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: kbrockman@mcw.edu.

PMID: 31879085
PMCID: PMC7062565
DOI: 10.1016/j.ijporl.2019.109838

Abstract

Objective: To perform a comprehensive review of the literature from July 2015 to June 2019 on the pathogenesis of otitis media. Bacteria, viruses and the role of the microbiome as well as the host response are discussed. Directions for future research are also suggested.

Data sources: PubMed database of the National Library of Medicine.

Review methods: PubMed was searched for any papers pertaining to OM pathogenesis between July 2015 and June 2019. If in English, abstracts were assessed individually for their relevance and included in the report. Members of the panel drafted the report based on these searches and on new data presented at the 20th International Symposium on Recent Advances in Otitis Media.

Conclusions: The main themes that arose in OM pathogenesis were around the need for symptomatic viral infections to develop disease. Different populations potentially having different mechanisms of pathogenesis. Novel bacterial otopathogens are emerging and need to be monitored. Animal models need to continue to be developed and used to understand disease pathogenesis.

Implications for practice: The findings in the pathogenesis panel have several implications for both research and clinical practice. The most urgent areas appear to be to continue monitoring the emergence of novel otopathogens, and the need to develop prevention and preventative therapies that do not rely on antibiotics and protect against the development of the initial OM episode.

Keywords: Host; Immune responses; Microbes; Otitis media; Pathogenesis.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest Ruth B Thornton: Nothing to disclose. Johanna Nokso-Koivisto: None. Kristian Riesbeck has received recent funding from Pfizer (Sweden), and has taken part in scientific advisory boards arranged by GSK (Belgium) and Merck (USA). Peter Richmond has served on vaccine scientific advisory boards and received institutional funding for investigator-initiated grants, from GlaxoSmithKline and Pfizer. Kenneth L Brockman: Nothing to disclose.

Cited by

Editorial: Otitis Media Genomics and the Middle Ear Microbiome.
Santos-Cortez RLP, Ehrlich GD, Ryan AF. Santos-Cortez RLP, et al. Front Genet. 2021 Oct 12;12:763688. doi: 10.3389/fgene.2021.763688. eCollection 2021. Front Genet. 2021. PMID: 34712274 Free PMC article. No abstract available.
Predominant Bacterial and Viral Otopathogens Identified Within the Respiratory Tract and Middle Ear of Urban Australian Children Experiencing Otitis Media Are Diversely Distributed.
Ngo CC, Massa HM, McMonagle BA, Perry CF, Nissen MD, Sloots TP, Thornton RB, Cripps AW. Ngo CC, et al. Front Cell Infect Microbiol. 2022 Mar 11;12:775535. doi: 10.3389/fcimb.2022.775535. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35360096 Free PMC article.
Outer membrane vesicles in gram-negative bacteria and its correlation with pathogenesis.
Abolhasani FS, Vaghefinanekaran N, Yarahmadi A, Akrami S, Mirmahdavi S, Yousefi MH, Afkhami H, Shafiei M. Abolhasani FS, et al. Front Immunol. 2025 Apr 1;16:1541636. doi: 10.3389/fimmu.2025.1541636. eCollection 2025. Front Immunol. 2025. PMID: 40236702 Free PMC article. Review.
Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion.
Enoksson F, Ruiz Rodriguez A, Peno C, Balcazar Lopez C, Tjernström F, Bogaert D, Hakansson AP, Bergenfelz C. Enoksson F, et al. Infect Immun. 2020 Sep 18;88(10):e00147-20. doi: 10.1128/IAI.00147-20. Print 2020 Sep 18. Infect Immun. 2020. PMID: 32661126 Free PMC article.
An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence.
Morin CD, Déziel E, Gauthier J, Levesque RC, Lau GW. Morin CD, et al. Virulence. 2021 Dec;12(1):1469-1507. doi: 10.1080/21505594.2021.1926408. Virulence. 2021. PMID: 34180343 Free PMC article. Review.

See all "Cited by" articles

References

1. Haas J., Braun S., Wutzler P. Eur. J. Health Econ.: HEPAC.Health Econ.Prev. Care. 2016;17:669–679. 2016. - PMC - PubMed
1. Yatsyshina S., Mayanskiy N., Shipulina O., Kulichenko T., Alyabieva N., Katosova L., Lazareva A., Skachkova T., Elkina M., Matosova S., Shipulin G. Diagn. Microbiol. Infect. Dis. 2016;85:125–130. 2016. - PMC - PubMed
1. van Dongen T.M., Venekamp R.P., Wensing A.M., Bogaert D., Sanders E.A., Schilder A.G. Pediatr. Infect. Dis. J. 2015;34:355–360. 2015. - PubMed
1. Toivonen L., Karppinen S., Schuez-Havupalo L., Teros-Jaakkola T., Vuononvirta J., Mertsola J., He Q., Waris M., Peltola V. Pediatr. Infect. Dis. J. 2016;35:e362–e369. 2016. - PubMed
1. Lappan R., Imbrogno K., Sikazwe C., Anderson D., Mok D., Coates H., Vijayasekaran S., Bumbak P., Blyth C.C., Jamieson S.E., Peacock C.S. BMC Microbiol. 2018;18:13. 2018. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Haas J., Braun S., Wutzler P. Eur. J. Health Econ.: HEPAC.Health Econ.Prev. Care. 2016;17:669–679. 2016. - PMC - PubMed

[2] Haas J., Braun S., Wutzler P. Eur. J. Health Econ.: HEPAC.Health Econ.Prev. Care. 2016;17:669–679. 2016. - PMC - PubMed

[3] Yatsyshina S., Mayanskiy N., Shipulina O., Kulichenko T., Alyabieva N., Katosova L., Lazareva A., Skachkova T., Elkina M., Matosova S., Shipulin G. Diagn. Microbiol. Infect. Dis. 2016;85:125–130. 2016. - PMC - PubMed

[4] Yatsyshina S., Mayanskiy N., Shipulina O., Kulichenko T., Alyabieva N., Katosova L., Lazareva A., Skachkova T., Elkina M., Matosova S., Shipulin G. Diagn. Microbiol. Infect. Dis. 2016;85:125–130. 2016. - PMC - PubMed

[5] van Dongen T.M., Venekamp R.P., Wensing A.M., Bogaert D., Sanders E.A., Schilder A.G. Pediatr. Infect. Dis. J. 2015;34:355–360. 2015. - PubMed

[6] van Dongen T.M., Venekamp R.P., Wensing A.M., Bogaert D., Sanders E.A., Schilder A.G. Pediatr. Infect. Dis. J. 2015;34:355–360. 2015. - PubMed

[7] Toivonen L., Karppinen S., Schuez-Havupalo L., Teros-Jaakkola T., Vuononvirta J., Mertsola J., He Q., Waris M., Peltola V. Pediatr. Infect. Dis. J. 2016;35:e362–e369. 2016. - PubMed

[8] Toivonen L., Karppinen S., Schuez-Havupalo L., Teros-Jaakkola T., Vuononvirta J., Mertsola J., He Q., Waris M., Peltola V. Pediatr. Infect. Dis. J. 2016;35:e362–e369. 2016. - PubMed

[9] Lappan R., Imbrogno K., Sikazwe C., Anderson D., Mok D., Coates H., Vijayasekaran S., Bumbak P., Blyth C.C., Jamieson S.E., Peacock C.S. BMC Microbiol. 2018;18:13. 2018. - PMC - PubMed

[10] Lappan R., Imbrogno K., Sikazwe C., Anderson D., Mok D., Coates H., Vijayasekaran S., Bumbak P., Blyth C.C., Jamieson S.E., Peacock C.S. BMC Microbiol. 2018;18:13. 2018. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019

Affiliations

Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical