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Review
. 2019 Jul 1:17:17-21.
doi: 10.1016/j.jor.2019.06.030. eCollection 2020 Jan-Feb.

Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

Steven J Girdler  1 , Ivan Ye  1 , Ray Tang  1 , Noah Kirschner  2
Affiliations
Review

Altering the natural history of rheumatoid arthritis: The role of immunotherapy and biologics in orthopaedic care

Steven J Girdler et al. J Orthop. .

Erratum in

Abstract

Rheumatoid Arthritis (RA) is an idiopathic disease characterized by systemic inflammation, persistent synovitis, and the presence of autoantibodies. Because of the musculoskeletal deformity caused by RA, multiple orthopaedic procedures are regularly performed as part of the treatment. The changing rates of surgery and the rise in new efficacious medical therapy have improved the prognosis for patients with RA. This review will discuss the natural history of rheumatoid arthritis, common medications used to treat it, how disease progression has changed as a function of new biologic immunotherapy, and the role of orthopaedic intervention in this new landscape of advanced rheumatoid care.

Keywords: Biologics; Immunotherapy; Rheumatoid arthritis.

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Figures

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Fig. 1
Abatacept mechanism of action.
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