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Case Reports
. 2020 Feb;22(1):e13238.
doi: 10.1111/tid.13238. Epub 2020 Jan 7.

Disseminated adenovirus infection after autologous stem cell transplant

Nicole J Kim  1 , Teresa S Hyun  2   3 , Steven A Pergam  2   4   5 , Rachel B Issaka  1   2   6
Affiliations
Case Reports

Disseminated adenovirus infection after autologous stem cell transplant

Nicole J Kim et al. Transpl Infect Dis. 2020 Feb.

Abstract

Adenovirus is an infrequent but challenging viral complication of transplantation that is rarely reported after autologous stem cell transplant. We present a case of disseminated adenovirus infection in a woman who received an autologous stem cell transplant for treatment of multiple sclerosis. After presenting with post-transplant episodic diarrhea and viremia, endoscopic biopsies and immunohistochemical staining confirmed the diagnosis of disseminated adenovirus infection. Her symptoms and viremia resolved after treatment with cidofovir. This case demonstrates that a high index of suspicion, a systematic clinical approach, and immunohistochemical tissue staining are necessary to diagnose disseminated adenovirus infection in an unexpected host.

Keywords: adenovirus; autologous stem cell transplant; diarrhea.

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References

REFERENCES

    1. Hiwarkar P, Kosulin K, Cesaro S, et al. Management of adenovirus infection in patients after haematopoietic stem cell transplantation: State-of-the-art and real-life current approach: a position statement on behalf of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation. Rev Med Virol. 2018;28(3):e1980.
    1. Sedlacek P, Petterson T, Robin M, et al. Incidence of adenovirus infection in hematopoietic stem cell transplantation recipients: findings from the advance study. Biol Blood Marrow Transplant. 2019;25(4):810-818.
    1. Lion T. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev. 2014;27(3):441-462.
    1. Hemmersbach-Miller M, Bailey ES, Kappus M, Prasad VK, Gray GC, Alspaugh JA. Disseminated adenovirus infection after combined liver-kidney transplantation. Front Cell Infect Microbiol. 2018;8:408.
    1. Yasuda S, Najima Y, Konishi T, et al. Disseminated adenovirus infection in a patient with relapsed refractory multiple myeloma undergoing autologous stem cell transplantation and pomalidomide/dexamethasone as salvage regimens. J Infect Chemother. 2019;25(5):371-375.

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