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. 2020 Apr;48(4):300060519892419.
doi: 10.1177/0300060519892419. Epub 2019 Dec 27.

Prognostic value of 18F-FDG PET/CT metabolic parameters in small cell lung cancer

Eun Kyoung Choi  1 , Minjae Park  2 , Jooyeon Jamie Im  1 , Yong-An Chung  1 , Jin Kyoung Oh  1
Affiliations

Prognostic value of 18F-FDG PET/CT metabolic parameters in small cell lung cancer

Eun Kyoung Choi et al. J Int Med Res. 2020 Apr.

Abstract

Objective: To compare the prognostic values of metabolic parameters from pretreatment PET/CT between limited disease (LD) and extensive disease (ED) small cell lung cancer (SCLC) patients.

Methods: Data on 118 newly diagnosed SCLC patients (50 LD and 68 ED) who underwent pretreatment positron emission tomography-computed tomography (PET/CT) were reviewed. For PET, metabolic parameters were measured for: (1) primary tumor, maximum standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis; and (2) all tumor lesions, SUVmax of the hottest tumor, whole body metabolic tumor volume (WBMTV), and whole body total lesion glycolysis (WBTLG). Prognostic values of metabolic parameters and other clinical variables were analyzed to predict overall survival (OS).

Results: In LD, SUVmax of the primary tumor was an independent prognostic factor for OS. Patients with high SUVmax showed significantly worse OS than those with low SUVmax. In ED, WBMTV and WBTLG were independent prognostic factors for OS. Patients with high WBMTV or WBTLG showed significantly worse OS than those with low WBMTV or WBTLG.

Conclusions: SUVmax of primary tumor was the only independent prognostic factor for OS in LD SCLC patients. WBMTV and WBTLG were independent prognostic factors in ED SCLC patients.

Keywords: Small cell lung carcinoma; extensive disease; fluorodeoxyglucose F18; limited disease; positron emission tomography–computed tomography; prognosis.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Cumulative overall survival curves according to SUVmax in patients with limited disease.
Figure 2.
Figure 2.
Cumulative overall survival curves according to WBMTV in patients with extensive disease.
Figure 3.
Figure 3.
Cumulative overall survival curves according to WBTLG in patients with extensive disease.
See this image and copyright information in PMC

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