doi: 10.1016/0041-0101(88)90278-4.
Purification and partial biochemical characterization of an edema inducing phospholipase A2 from Vipera russelli (Russell's viper) snake venom
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- PMID: 3188061
- DOI: 10.1016/0041-0101(88)90278-4
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Purification and partial biochemical characterization of an edema inducing phospholipase A2 from Vipera russelli (Russell's viper) snake venom
Toxicon.
1988.
Abstract
A phospholipase A2 (VRV PL-VI) from Vipera russelli venom was purified to homogeneity in a single step on CM-Sephadex C-25 column. VRV PL-VI is a basic protein with a mol. wt of about 12,000 and showed a basic pH optimum and a high temperature maximum. It hydrolysed purified phospholipids in the order of phosphatidylethanolamine greater than phosphatidylcholine much greater than phosphatidylserine greater than phosphatidylinositol = 0. It is toxic with an LD50 value (i.p.) of 3.5 micrograms/g body weight in mice and it induced persistent edema in the mouse foot pad.
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