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Clinical Trial
. 1977 Jan;185(1):128-31.
doi: 10.1097/00000658-197701000-00021.

Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study

L H Toledo-Pereyra, R L Simmons, L C Olson, J S Najarian
Clinical Trial

Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study

L H Toledo-Pereyra et al. Ann Surg. 1977 Jan.

Abstract

We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized, double-blind, prospective plan. There was no difference in the short-term or long-term function of either group of kidneys. Allopurinol does not appear to have as consistent a beneficial effect on non-ischemically damaged human kidneys as that observed experimentally on ischemically damaged canine organs.

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References

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