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Case Reports
. 2020 Apr;59(2):102694.
doi: 10.1016/j.transci.2019.102694. Epub 2019 Dec 13.

Thrombotic thrombocytopenic purpura associated with pesticides: A report of 4 cases and literature review

Volkan Karakuş  1 , Egemen Kaya  2 , Gizem Zorlu Görgülügil  3 , Yelda Dere  4 , Erdal Kurtoğlu  5
Affiliations
Case Reports

Thrombotic thrombocytopenic purpura associated with pesticides: A report of 4 cases and literature review

Volkan Karakuş et al. Transfus Apher Sci. 2020 Apr.

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a disease characterized by the presence of microangiopathic hemolytic anemia (MAHA) and thrombocytopenia, caused by the congenital or acquired decrease of the enzyme activity which degrades unusual large vWF multimers. There is no identifiable cause in half of the acquired TTP cases. Herein, we report four possible pesticide-related cases with decreased ADAMTS13 enzyme activity, increased titer of ADAMTS13 inhibitor and typical clinical and laboratory presentation.

Keywords: ADAMTS-13; Pesticide; Thrombotic thrombocytopenic purpura.

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Conflict of interest statement

Declaration of Competing Interest No conflict of interest exist.

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