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. 2019 Dec 27;9(1):20113.
doi: 10.1038/s41598-019-56623-4.

Eye lens radiation exposure in paediatric interventional treatment of retinoblastoma

A Obesso  1 , L Alejo  2 , C Huerga  1 , F Sánchez-Muñoz  1 , E Corredoira  1 , A Fernández-Prieto  3 , R Frutos  3 , B Marín  3 , G Garzón  3 , J Peralta  4 , C Ubeda  5 , E Guibelalde  6
Affiliations

Eye lens radiation exposure in paediatric interventional treatment of retinoblastoma

A Obesso et al. Sci Rep. .

Abstract

Retinoblastoma represents 3% of cancers in children under fifteen years of age. The standard paediatric treatment for saving the affected eye is supraselective intra-arterial chemotherapy performed in interventional rooms. In order to address the radiation toxicity due to the angiography, the aim of this study was to determine the typical dose value corresponding to the procedure, estimate the paediatric patients' eye lens dose and study the relationship between dose indicators and dose to the lens. An automatic dose management software was installed in two interventional rooms to obtain the distribution of the dose indicators kerma-area product and reference-point air kerma, getting a typical value 16 Gy·cm2 and 130 mGy, respectively (n = 35). The eye lens dose estimates were obtained with photoluminescent dosimeters placed on the patient's eyelids. In the left eye, the entrance surface air kerma was 44.23 ± 2.66 mGy, and 12.72 ± 0.89 mGy in the right eye (n = 10). There was a positive correlation between dose to the lens per procedure and dose indicators, with R2 > 0.65 for both eyes. Based on this information, the threshold for the onset of radiation-induce cataracts (500 mGy) will be exceeded if the treatment is performed for more than 8 sessions.

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Conflict of interest statement

The Balt-Extrusion company has financed the publication fees of this study. The authors do not declare any non-financial competing interest.

Figures

Figure 1
Figure 1
Dose indicators distribution in terms of Ka,r and PKA.
Figure 2
Figure 2
Correlation between Ka,e measured on the left eye and PKA.
Figure 3
Figure 3
Correlation between Ka,e measured on the right eye and PKA.
Figure 4
Figure 4
Correlation between Ka,e measured on the left eye and Ka,r.
Figure 5
Figure 5
Correlation between Ka,e measured on the right eye and Ka,r.
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