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Case Reports
. 2019 Dec 28;19(1):148.
doi: 10.1186/s12902-019-0482-0.

Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series

Yimin Shen  1   2 , Xiaoxiao Song  1 , Yuezhong Ren  3
Affiliations
Case Reports

Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series

Yimin Shen et al. BMC Endocr Disord. .

Abstract

Background: Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia and is characterized by the presence of insulin autoantibodies. Patients with IAS usually complain of hypoglycemia without any previous insulin received. Glucocorticoids and immunosuppressants are used to treat IAS.

Case presentation: We report four patients with diabetes who were diagnosed with non-classical IAS and describe the treatment of these patients. Moreover, the differential diagnosis with hyperinsulinism is discussed.

Conclusion: High levels of insulin autoantibodies, as well as hyperinsulinemic hypoglycemia, are found in patients with diabetes mellitus and prior exogenous insulin exposure. This situation that we classified as non-classical IAS should be attached importance to.

Keywords: Acarbose; Diabetes; Glucose; Hyperinsulinism; Hypoglycemia; Insulin autoimmune syndrome; Steroid.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Wong SL, Priestman A, Holmes DT. Recurrent hypoglycemia from insulin autoimmune syndrome. J Gen Intern Med. 2014;29(1):250–254. doi: 10.1007/s11606-013-2588-9. - DOI - PMC - PubMed
    1. Gullo D, Evans JL, Sortino G, Goldfine ID, Vigneri R. Insulin autoimmune syndrome (Hirata disease) in European Caucasians taking alpha-lipoic acid. Clin Endocrinol. 2014;81(2):204–209. doi: 10.1111/cen.12334. - DOI - PubMed
    1. Su CT, Lin YC. Hyperinsulinemic hypoglycemia associated with insulin antibodies caused by exogenous insulin analog. Endocrinol Diabetes Metab Case Rep. 2016;2016. - PMC - PubMed
    1. Woo CY, Jeong JY, Jang JE, Leem J, Jung CH, Koh EH, et al. Clinical features and causes of endogenous hyperinsulinemic hypoglycemia in Korea. Diabetes Metab J. 2015;39(2):126–131. doi: 10.4093/dmj.2015.39.2.126. - DOI - PMC - PubMed
    1. Matej A, Bujwid H, Wronski J. Glycemic control in patients with insulinoma. Horm (Athens) 2016;15(4):489–499. doi: 10.14310/horm.2002.1706. - DOI - PubMed

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