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Review
. 2020 Feb;36(2):85-87.
doi: 10.1016/j.pt.2019.12.006.

Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone

Nicolas M B Brancucci  1 , Volker T Heussler  2 , Christof Grüring  3
Affiliations
Review

Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone

Nicolas M B Brancucci et al. Trends Parasitol. 2020 Feb.

Abstract

A recent report by Jennison et al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these stages and that specific PMV inhibitors block parasite transmission to mosquitoes.

Keywords: Anopheles mosquito; Plasmodium export element; aspartyl protease; gametocyte-exported proteins; malaria transmission; plasmepsin V.

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