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Review
. 2019 Dec 4:2019:9896757.
doi: 10.1155/2019/9896757. eCollection 2019.

Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review

Pei-En Chen  1   2 , Chia-Yu Liu  3 , Wu-Hsiung Chien  4 , Ching-Wen Chien  5 , Tao-Hsin Tung  1   6
Affiliations
Review

Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review

Pei-En Chen et al. Evid Based Complement Alternat Med. .

Abstract

Background: Previous studies have reported the use of complementary therapies to reduce the risk of gout attacks. In this study, we assessed the effectiveness of cherries in reducing uric acid levels associated with gout.

Methods: We searched for relevant studies on PubMed, Embase, and the Cochrane Library without restrictions on language from inception until August 15, 2019. The risk of bias was evaluated using the PRISMA statement and checklist, and the methodological quality was assessed using the Cochrane Collaboration tool.

Results: The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration.

Conclusions: Current evidence supports an association between cherry intake and a reduced risk of gout attacks. Note however that we were unable to conduct effective meta-analysis due to a lack of relevant studies and a high degree of variation in the methodologies and metrics used in previous studies. Further comprehensive trials or long-term follow-up studies will be required to evaluate the efficacy of cherry intake in treating patients with gout or hyperuricemia.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA study flow chart.
Figure 2
Figure 2
Risk of bias summary.
See this image and copyright information in PMC

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