Resolution of pathogenic R-loops rescues motor neuron degeneration in spinal muscular atrophy

Niko Hensel^{1

2}, Nora Tula Detering^{1

2}, Lisa Marie Walter^{1

2}, Peter Claus^{1

2}

Affiliations

¹ Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany.
² Center of Systems Neuroscience (ZSN), Hannover, Germany.

Comment

Niko Hensel et al. Brain. 2020.

. 2020 Jan 1;143(1):2-5.

doi: 10.1093/brain/awz394.

Niko Hensel^{1

2}, Nora Tula Detering^{1

2}, Lisa Marie Walter^{1

2}, Peter Claus^{1

2}

¹ Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany.
² Center of Systems Neuroscience (ZSN), Hannover, Germany.

Erratum in

Erratum.
[No authors listed] [No authors listed] Brain. 2020 Mar 1;143(3):e24. doi: 10.1093/brain/awaa007. Brain. 2020. PMID: 32333675 Free PMC article. No abstract available.

No abstract available

ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy.
Kannan A, Jiang X, He L, Ahmad S, Gangwani L. Kannan A, et al. Brain. 2020 Jan 1;143(1):69-93. doi: 10.1093/brain/awz373. Brain. 2020. PMID: 31828288 Free PMC article.