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Review
. 2020 Jan;62(1):4-14.
doi: 10.1111/dgd.12644. Epub 2019 Dec 30.

Decoding the Notch signal

Julia Falo-Sanjuan  1 , Sarah J Bray  1
Affiliations
Review

Decoding the Notch signal

Julia Falo-Sanjuan et al. Dev Growth Differ. 2020 Jan.

Abstract

Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.

Keywords: Notch; gene regulation; signalling; transcription.

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References

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