Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2019 Dec 16;11(12):3069.
doi: 10.3390/nu11123069.

Amaranth Oil Increases Total and LDL Cholesterol Levels without Influencing Early Markers of Atherosclerosis in an Overweight and Obese Population: A Randomized Double-Blind Cross-Over Study in Comparison with Rapeseed Oil Supplementation

Monika Dus-Zuchowska  1 , Jaroslaw Walkowiak  1 , Anna Morawska  2 , Patrycja Krzyzanowska-Jankowska  1 , Anna Miskiewicz-Chotnicka  1 , Juliusz Przyslawski  2 , Aleksandra Lisowska  1
Affiliations
Randomized Controlled Trial

Amaranth Oil Increases Total and LDL Cholesterol Levels without Influencing Early Markers of Atherosclerosis in an Overweight and Obese Population: A Randomized Double-Blind Cross-Over Study in Comparison with Rapeseed Oil Supplementation

Monika Dus-Zuchowska et al. Nutrients. .

Abstract

Background: Atherosclerosis (AT) is a chronic inflammatory process in which oxidative stress is the key event. Amaranth oil (AmO) has potential hypolipidemic and antiatherogenic effects. The aim of the study was to compare the effects of AmO and rapeseed oil (RaO) supplementation on expression of early markers of AT and lipid profile in obese or overweight subjects.

Methods: A randomized, double-blinded cross-over study was conducted, in which participants took 20 mL of AmO in the first arm and 20 mL RaO in the second arm, switching after the washout period. Serum concentrations of adhesion molecules (sP-selectin, sVCAM-1), high-sensitivity C-reactive protein (hsCRP), asymmetric dimethylarginine (ADMA), and lipid profile were assessed before and after nutritional interventions. In addition, anthropometric parameters were measured.

Results: The total (TC) and low-density lipoprotein (LDL) cholesterol concentrations increased significantly in the AmO group in comparison with RaO (ΔTC 5.52 ± 35 vs. -8.43 ± 17.65 mg/dL; p = 0.002 and 4.43 ± 34.96 vs. -7.55 ± 16.41 mg/dL; p = 0.002, respectively). There were no significant differences in other parameters analyzed between the groups.

Conclusion: The use of AmO instead of RaO may increase cardiovascular risk in obese and overweight subjects.

Keywords: amaranth oil; atherosclerosis; obesity.

PubMed Disclaimer

Conflict of interest statement

M.D.-Z. reports personal fees and nonfinancial support from Nestle, Recordati, and Nutricia. J.W. reports personal fees and nonfinancial support from Biocodex, BGP Products, Chiesi, Hipp, Humana, Mead Johnson Nutrition, Merck Sharp & Dohme, Nestle, Nutricia, Roche, Sequoia Pharmaceuticals, and Vitis Pharma, outside the submitted work, and also grant and personal fees from Norsa Pharma and Nutricia Research Foundation Poland, also outside the submitted work. P.K.-J. & J.P. declare no conflict of interest. A.L. reports personal fees from Norsa Pharma and grant from Nutricia Research Foundation Poland, outside the submitted work. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Study flowchart.
See this image and copyright information in PMC

References

    1. Hruby A., Hu F.B. The Epidemiology of Obesity: A Big Picture. Pharmacoeconomics. 2015;33:673–689. doi: 10.1007/s40273-014-0243-x. - DOI - PMC - PubMed
    1. Stevens G.A., Singh G.M., Lu Y., Danaei G., Lin J.K., Finucane M.M., Bahalim A.N., McIntire R.K., Gutierrez H.R., Cowan M., et al. National, regional, and global trends in adult overweight and obesity prevalences. Popul. Health Metr. 2012;10:22. doi: 10.1186/1478-7954-10-22. - DOI - PMC - PubMed
    1. Fan J., Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. J. Atheroscler. Thromb. 2003;10:63–71. doi: 10.5551/jat.10.63. - DOI - PubMed
    1. Cybulsky M.I., Gimbrone M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251:788–791. doi: 10.1126/science.1990440. - DOI - PubMed
    1. Nie Q., Fan J., Haraoka S., Shimokama T., Watanabe T. Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies in hypercholesterolemic rats: Implications of the ICAM-1 and LFA-1 pathway in atherogenesis. Lab. Investig. 1997;77:469–482. - PubMed

Publication types

MeSH terms

LinkOut - more resources