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Clinical Trial
. 1977 Jan 1;1(6052):10-2.
doi: 10.1136/bmj.1.6052.10.

Increased sensitivity to nitrazepam in old age

C M Castleden, C F George, D Marcer, C Hallett
Clinical Trial

Increased sensitivity to nitrazepam in old age

C M Castleden et al. Br Med J. .

Abstract

The effects of a single 10 mg oral dose of nitrazepam were compared with those of a placebo in healthy young and old people. Both the young and the elderly slept better on three successive nights after nitrazepam but they felt less awake at 12 and 36 hours (P less than 0-01). Elderly people made significantly more mistakes in a psychomotor test than did the young, despite similar plasma concentrations of nitrazepam and half lives in the two groups. This difference in response to psychomotor testing is probably explained by an increased sensitivity of the ageing brain to the action of nitrazepam.

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References

    1. J Chromatogr. 1974 Nov 6;99(0):447-60 - PubMed
    1. Jpn J Pharmacol. 1968 Dec;18(4):389-96 - PubMed
    1. J Clin Invest. 1950 May;29(5):496-507 - PubMed
    1. Pharmacology. 1972;8(4):273-9 - PubMed
    1. Psychopharmacologia. 1972;25(2):117-32 - PubMed

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