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. 2020 Jan;27(1):163-172.
doi: 10.1016/j.sjbs.2019.06.013. Epub 2019 Jun 19.

Phytochemical profiling, antioxidant and HepG2 cancer cells' antiproliferation potential in the kernels of apricot cultivars

Yongsheng Chen  1 , Abdullah Ahmed Al-Ghamdi  2 , Mohamed S Elshikh  2 , Munir H Shah  3 , Monerah A Al-Dosary  2 , Arshad Mehmood Abbasi  4
Affiliations

Phytochemical profiling, antioxidant and HepG2 cancer cells' antiproliferation potential in the kernels of apricot cultivars

Yongsheng Chen et al. Saudi J Biol Sci. 2020 Jan.

Abstract

Phytochemical composition, in vitro antioxidant and antiproliferative activity against HepG2 cells were studied in the kernels of apricot cultivars grown in the northern areas of Pakistan. Relatively, the kernel of Habbi cultivar/AP-12 depicted significant potential to scavenge DPPH and ABTS+ free radicals as well as oxygen radical absorbance capacity along with highest contents of total flavonoids, phenolics, chlorogenic and syringic acids on dry weight basis. The average concentration of quercetin ranged 0.072-1.343 mg/100 g, and of EGCG from 0.713 to 6.521 mg/100 g with maximum concentration in Hulappa/AP-3 and Kho Chali-Khatta 3/AP-17, respectively. Amygdalin content was highest (1145 mg/100 g) in the kernel of Balaani/AP-14. Highest inhibition of HepG2 cells was found in the kernel of Waflu Chuli/AP-9 (EC50 = 15.70 ± 3.77 mg/mL). The PCA showed significant contributions of polyphenols and flavonoids towards biochemical assays, while CA revealed similarities and associations among various cultivars. Our study revealed that Habbi, Waflu Chuli, Thukdeena and Balaani kernels are rich sources of bioactive compounds and possess significant antioxidant and anticancer activity and can contribute considerably in the prevention and treatment of chronic health disorders.

Keywords: Amygdalin; Antioxidant; Antiproliferation; Apricot; Kernels; Polyphenolics.

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Figures

Fig. 1
Fig. 1
Total phenolics content of AP varieties (A); Total flavonoids content of AP varieties (B); Percent contribution of flavonoids to phenolics (C) (mean ± SD; n = 3). Bars with different letters differ significantly at p < 0.05.
Fig. 2
Fig. 2
DPPH scavenging activity EC50 values of AP cultivars (A); ABTS scavenging activity EC50 values of AP cultivars (B); ORAC values of AP cultivars (C) (mean ± SD; n = 3). Bars with different letters differ significantly at p < 0.05.
Fig. 3
Fig. 3
Dendrogram of hierarchical cluster analysis of AP extracts based on different phytochemicals and biochemical properties.
See this image and copyright information in PMC

References

    1. Abbasi A.M., Liu F., Guo X., Fu X., Li T., Liu R.H. Phytochemical composition, cellular antioxidant capacity and antiproliferative activity in mango (Mangifera indica L.) pulp and peel. Int. J. Food Sci. Tech. 2017;52(3):817–826.
    1. Abbasi A.M., Shah M.H., Guo X., Khan N. Comparison of nutritional value, antioxidant potential, and risk assessment of the Mulberry (Morus) fruits. Int. J. Fruit Sci. 2015;16(2):113–134.
    1. Ali S., Masud T., Abbasi K.S. Physico-chemical characteristics of apricot (Prunus armeniaca L.) grown in Northern Areas of Pakistan. Sci. Horticult. 2011;130(2):386–392.
    1. Ali S., Masud T., Abbasi K.S., Mahmood T., Ali A. Some physico-chemical and functional attributes of six indigenous apricot genotypes from Gilgit-Baltistan, Pakistan. Int. J. Biosci. 2014;4(2):221–231.
    1. Arts I.C.W., Putte B.V.D., Hollman P.C.H. Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. J. Agri Food Chem. 2000;48(5):1746–1751. - PubMed

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