Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Aug;25(1-2):1-3.
doi: 10.1007/BF01969085.

Histamine in carcinoid syndrome

J Gustafsen  1 , S Boesby, W K Man
Affiliations

Histamine in carcinoid syndrome

J Gustafsen et al. Agents Actions. 1988 Aug.

Abstract

The exact etiology of carcinoid flushing remains unknown, but the symptoms are probably mediated through release of one or several humoral substances. Flushing seen in fore-gut carcinoids (gastric carcinoids) has been ascribed to excessive histamine release, whereas flushing seen in mid-gut carcinoids (ileal carcinoids) tentatively has been ascribed to excessive release of serotonin, bradykinin, substance P, substance K or eledoisin. In this study plasma histamine was measured in 8 patients with mid-gut carcinoids and carcinoid syndrome using an enzymatic isotopic method in order to evaluate histamine as the vasoactive agent in patients with ileal carcinoid tumours and carcinoid syndrome. All patients had raised plasma histamine values. In patients with mid-gut carcinoids histamine may be one of the substances mediating flushing.

PubMed Disclaimer

References

    1. Adv Pharmacol. 1967;5:109-28 - PubMed
    1. Acta Med Scand. 1956 Dec 8;156(2):73-83 - PubMed
    1. J Clin Invest. 1966 Feb;45(2):173-8 - PubMed
    1. Anal Biochem. 1979 Apr 15;94(2):425-30 - PubMed
    1. Lancet. 1968 Nov 16;2(7577):1053-4 - PubMed