Seminoma metastasized to the prostate: A case report and literature review

Abstract

The testicular seminomas are germ-cell tumors which account for approximately 50% of all testicular tumors. Most primary testicular germ cell tumors metastasize through a lymphatic system in a predictable pattern with the retroperitoneal lymph nodes being the most common initial metastatic site. Hematological metastasis to the distant organs is less common, and except for pulmonary metastasis, changes the classification from good to intermediate prognosis. Metastasis of testicular seminoma to the prostate is an extremely rare entity with only five reported cases in the literature. In this report, we present a 63-year-old male with recurrent testicular seminoma presenting in prostate.

Fig. 1

MRI of the pelvis (A) showed a 3 cm mass (red arrow) at the right basilar central zone of prostate. The mass was hyperintense in PET-CT scan involving the base of the prostate and seminal vesicle. (B, black arrow). Bilateral pelvic lymphadenopathies were noted in surveillance CT-scan (C) and they were hyperintense in PET-CT scan. (D, red arrowhead). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 2

Tumor cells show pink to focally clear cytoplasm, vesicular nuclei and lymphocytic infiltration (A). Tumor cells are positive for PLAP (B), OCT3/4 (C) and CD117 (D), and negative for pancytokeratin (not shown). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)