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. 2019 Dec;6(4):146-150.
doi: 10.1016/j.ijpam.2019.09.001. Epub 2019 Sep 12.

Clinical significance of IgM deposition in pediatric minimal change disease

Duaa M Al Romaili  1 , Turki O Al-Hussain  2 , Hazem S Awad  1 , Sermin A Saadeh  1 , Ibrahim A Al-Hassoun  1 , Turki A Al-Shareef  1
Affiliations

Clinical significance of IgM deposition in pediatric minimal change disease

Duaa M Al Romaili et al. Int J Pediatr Adolesc Med. 2019 Dec.

Abstract

Background: Idiopathic nephrotic syndrome (INS) is a common pediatric disease. Minimal change disease (MCD) is the most common histopathological subtype and usually has good prognosis. However, in less common presentations, INS may have an unusual course that makes renal biopsy a necessity to identify its etiology. Immunoglobulin M (IgM) occasionally deposits in the mesangium and can be seen under immunofluorescence (IF). The role of IgM is controversial in MCD. It is likely associated with less favorable outcomes for MCD. This study aims to investigate the clinical significance of mesangial IgM deposits on the outcome of MCD in a pediatric population.

Methods: In this retrospective cohort study, we obtained native kidney biopsy samples from 192 children who were diagnosed with MCD from 2003 to 2014. The samples were divided into groups according to the histopathological deposition of IgM in biopsies under IF. The group for which biopsies showed IgM was labeled as IgM + IF (n = 77), and the group for which biopsies were without IgM was labeled as IgM-IF (n = 115). We reviewed hypertension, hematuria, and estimated glomerular filtration rate (eGFR) at the time of presentation to our institute; response to steroid therapy (remission, dependence, frequent relapses, and resistance) and response after adjuvant immunosuppressive therapy (complete remission, partial remission, frequent relapses, and no response) when indicated; development of chronic kidney disease (CKD) and end-stage renal disease during the course of the disease (ESRD).

Results: Our results showed that mesangial IgM deposition in MCD showed significant statistical association with hypertension at the time of presentation (P = .05). There was statistically significant association between the presence of IgM deposition and the development of steroid dependence (P = .05) and CKD during the course of the disease (P = .05).

Conclusions: Our study showed that IgM deposition in MCD showed statistical association with hypertension by the time the patient presented to our institute, development of steroid dependence, and CKD. IgM may play a role in MCD. However, we recommend a prospective study to verify the role of IgM in MCD outcomes.

Keywords: IgM; IgM nephropathy; Minimal change disease; Nephrotic syndrome.

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Figures

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Case selection. (1. Khalifa M. Improving Emergency Room Performance by Reducing Patients' Length of Stay. Stud Health Technol Inform. 2015; 213:41–4. Epub 2015/07/15. PubMed PMID: 26152948.)
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References

    1. Park S.J., Shin J.I. Complications of nephrotic syndrome. Korean J Pediatr. 2011;54(8):322–328. Epub 2011/11/17, PubMed PMID: 22087198; PubMed Central PMCID: PMCPMC3212701. - PMC - PubMed
    1. Wynn S.R., Stickler G.B., Burke E.C. Long-term prognosis for children with nephrotic syndrome. Clin Pediatr (Phila). 1988;27(2):63–68. Epub 1988/02/01, PubMed PMID: 3338230. - PubMed
    1. Besbas N., Topaloglu R., Saatci O., Bakkaloglu A. Long-term follow-up in children with steroid-resistant nephrotic syndrome. Clin Pediatr (Phila). 1992;31(5):283–288. Epub 1992/05/01, PubMed PMID: 1582094. - PubMed
    1. Primary nephrotic syndrome in children: clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. A Report of the International Study of Kidney Disease in Children. Kidney Int. 1981;20(6):765–771. Epub 1981/12/01. PubMed PMID: 7334749. - PubMed
    1. Swartz S.J., Eldin K.W., Hicks M.J., Feig D.I. Minimal change disease with IgM+ immunofluorescence: a subtype of nephrotic syndrome. Pediatr Nephrol. 2009;24(6):1187–1192. Epub 2009/02/17, PubMed PMID: 19219463. - PubMed