Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec;6(4):151-154.
doi: 10.1016/j.ijpam.2019.10.003. Epub 2019 Nov 1.

Estimation of serum neopterin level as an early marker for detecting severe dengue infection

Channanayaka Chandrashekhar  1 , Korrayi Balaji  1 , Prajwala Hassan Vasudev  1 , George Mathew Panachiyil  2 , Tirin Babu  2
Affiliations

Estimation of serum neopterin level as an early marker for detecting severe dengue infection

Channanayaka Chandrashekhar et al. Int J Pediatr Adolesc Med. 2019 Dec.

Abstract

Background: This study aimed to determine the role of neopterin in the early assessment of dengue severity in children of age one month to 18 years admitted for fever and confirmed by dengue serology.

Method: Two sets of samples were collected from 77 confirmed dengue patients aged one month to 18 years for serum neopterin determination. The first sample was collected at 2-3 days of fever onset, and the second sample was collected at 24-36 h after the first sample was collected and followed up cases and correlated serum neopterin levels.

Results: Among the 77 patients enrolled, 19 were diagnosed with severe dengue, 15 patients as having dengue with warning signs, and 43 patients as having dengue fever.

Conclusion: In this study, we found that the serum neopterin levels were significantly higher in the severe dengue category (mean: 58.75(±4.91) nmol/l) than in the non-severe dengue category (mean: 48.11(±8.80) nmol/l). Furthermore, a positive correlation was observed between neopterin concentration and duration of fever hence, higher serum neopterin levels may indicate dengue severity. The determination of serum neopterin concentration may be used for the early assessment of severe dengue.

Keywords: Dengue fever; Early marker; Infection; Serum neopterin.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Heilman J.M., De Wolff J., Beards G.M., Basden B.J. Dengue fever: a Wikipedia clinical review. Open Med. 2014;8(4):e105. - PMC - PubMed
    1. Wilder-Smith A., Schwartz E. Dengue in travelers. N Engl J Med. 2005;353(9):924–932. - PubMed
    1. Patterson J., Sammon M., Garg M. Dengue, Zika and chikungunya: emerging arboviruses in the New World. West J Emerg Med. 2016;17(6):671. - PMC - PubMed
    1. Gyawali N., Bradbury R.S., Taylor-Robinson A.W. The epidemiology of dengue infection: harnessing past experience and current knowledge to support implementation of future control strategies. J Vector Borne Dis. 2016;53(4):293. - PubMed
    1. Kumar A., Rao C.R., Pandit V., Shetty S., Bammigatti C., Samarasinghe C.M. Clinical manifestations and trend of dengue cases admitted in a tertiary care hospital, Udupi district, Karnataka. Indian J Community Med. 2010;35(3):386. - PMC - PubMed