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. 2020 Jan 1;11(1):51-56.
doi: 10.7150/jca.31196. eCollection 2020.

CEA as a risk factor in predicting ocular metastasis from colorectal cancer

You-Lan Min  1 , Ying-Xin Gong  1 , Pei-Wen Zhu  1 , Qi Lin  1 , Biao Li  1 , Wen-Qing Shi  1 , Qing Yuan  1 , Yi Shao  1
Affiliations

CEA as a risk factor in predicting ocular metastasis from colorectal cancer

You-Lan Min et al. J Cancer. .

Abstract

Objective: Colorectal, closely following pulmonary and breast, is the third predilection site of cancer that lead to death all over the world. Ocular metastasis (OM) of colorectal cancer (CRC) is becoming increasingly common and presents a poor prognosis. In this study, we detected some recognized tumor biomarkers and tried to differentiate the discrepancy between CRC patients with and without OM in order to clarify the risk factor for OM in patients with colorectal cancer.

Methods: 1735 patients with colorectal cancer in total from August 2005 to August 2017 were involved in this study. Nonparametric rank sum test and Chi-square test were applied to prescribe whether there were significant differences between OM group and non-ocular metastasis (NOM) group. And binary logistic regression analysis was used to determine the risk factor. Then, we used receiver operating curve (ROC) to assess the diagnostic value of OM in CRC patients.

Results: The incidence of OM in CRC patients was 1.12%. No significant differences were found in gender, age, histopathological type, tumor classification and tumor differentiation between OM group and NOM group. Nonparametric rank sum test approved that OM group had higher serum CEA level compared with NOM group. Binary logistic regression indicated that CEA was a risk factor for OM in colorectal cancer patients (p<0.001). ROC curve showed that AUC of CEA was 0.877. The cutoff value of CEA was 12.45 ng/ml, whose sensitivity is 1.000 and its specificity is 0.877.

Conclusion: Based on our study, CEA was a risk factor of ocular metastasis in colorectal cancer patients.

Keywords: carcinoma embryonic antigen; colorectal cancer; independent risk factor; ocular metastasis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Clinical features of colorectal cancer OM patients and NOM patients. Notes: n=21 in OM group, n=1714 in NOM group. OM group included 16 orbital metastasis cases and 5 intraocular metastasis cases. Abbreviations: OM, ocular metastasis; NOM, non-ocular metastasis.
Figure 2
Figure 2
The HE staining and IHC images from colorectal cancer patients with ocular metastasis. Notes: A. Colorectal cancer (HE×200) B. CD56(+) (SP×200) The tissue was collected from ocular metastasis site of colorectal patients.
Figure 3
Figure 3
The receiver operating characteristics (ROC) curves of risk factor CEA for detecting OM in colorectal cancer. Notes: The area under the ROC curve were 0.934, (p < 0.001; 95% CI: 0.931-0.953) for CEA. Abbreviations: ROC, receiver operating characteristic; AUC, area under curve.
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