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Case Reports
. 2019 Sep 30;7(12):2300-2305.
doi: 10.1002/ccr3.2386. eCollection 2019 Dec.

Invasive mole in a perimenopausal woman with lung and vaginal metastases: A case report

Cristina Martínez Leocadio  1 , José García Villayzán  1 , Jesús García-Foncillas López  2 , Franklin Idrovo  3 , Javier Plaza Arranz  1 , Manuel Albi González  1
Affiliations
Case Reports

Invasive mole in a perimenopausal woman with lung and vaginal metastases: A case report

Cristina Martínez Leocadio et al. Clin Case Rep. .

Abstract

Gestational trophoblastic disease can result in serious complications and disease progression. Therefore, follow-up of such patients is essential for early detection of malignant trophoblastic tumors and to reduce mortality rate. Primary treatment is chemotherapy but hysterectomy should be considered in patients who have uncontrollable hemorrhage and hemodynamic instability.

Keywords: gestational trophoblastic neoplasia; hysterectomy; invasive mole; metastases; perimenopausal; trophoblastic disease.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Gestational trophoblastic disease spectrum
Figure 2
Figure 2
Abdominopelvic US: Vesicular pattern of multiple echoes
Figure 3
Figure 3
Thoracoabdominopelvic CT scan: Pelvic mass of 14 cm
Figure 4
Figure 4
Uterine curettage aspiration
Figure 5
Figure 5
Complete hydatidiform mole. Diffuse villous enlargement cistern formation, hydropic changes, and trophoblastic hyperplasia
Figure 6
Figure 6
Piece of hysterectomy: Intracavitary persistent gestational trophoblastic tissue. Intramyometrial vesicles invasion (arrow)
Figure 7
Figure 7
Invasive complete hydatidiform mole. Molar villi within the myometrium
Figure 8
Figure 8
Detail of vascular invasion
Figure 9
Figure 9
Thoracoabdominopelvic CT scan: Pulmonary nodules of 1.44 cm and 1.75 cm suggestive of pulmonary metastases
Figure 10
Figure 10
Vaginal metastases
Figure 11
Figure 11
Chronological explanation of events
See this image and copyright information in PMC

References

    1. Shih IM. Gestational trophoblastic neoplasia – pathogenesis and potential therapeutic targets. Lancet Oncol. 2007;8:642‐650. - PubMed
    1. Ngan H, Seckl MJ, Berkowitz RS, et al. Update on the diagnosis and management of gestational trophoblastic disease. FIGO CANCER REPORT 2018. Int J Gynecol Obstet. 2018;143:S2. - PubMed
    1. Kaur B, Short D, Fisher RA, Savage PM, Seckl MJ, Sebire NJ. Atypical placental site nodule (APSN) and association with malignant gestational trophoblastic disease. Int J Gynecol Pathol. 2015;34(2):152‐158. - PubMed
    1. Lurain J. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531‐539. - PubMed
    1. Sebire NJ, Fisher RA, Foskett M, Rees H, Seckl MJ, Newlands ES. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG. 2003;110:22‐26. - PubMed

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