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Review
. 2020 Feb;127(2):213-230.
doi: 10.1007/s00702-019-02133-6. Epub 2020 Jan 1.

6-Hydroxydopamine: a far from simple neurotoxin

Damir Varešlija  1   2 , Keith F Tipton  3 , Gavin P Davey  1 , Andrew G McDonald  1
Affiliations
Review

6-Hydroxydopamine: a far from simple neurotoxin

Damir Varešlija et al. J Neural Transm (Vienna). 2020 Feb.

Abstract

6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.

Keywords: 4-Hydroxynonenal; Aminochrome; Apoptosis; Autoxidation; Dopamine; Highly reactive oxygen species (hROS); Iron release; Mitochondria; Necrosis; Neurotoxicity; Oxidative damage; Parkinson’s disease; Peroxynitrite; Reactive oxygen species (ROS).

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References

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