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Comment
. 2021 Dec 1;274(6):e675-e676.
doi: 10.1097/SLA.0000000000003762.

Comment on "Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials"

Xiang-Dong Wu, Di Wu, Yong Liu  1 , Wei Huang  2
Affiliations
Comment

Comment on "Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials"

Xiang-Dong Wu et al. Ann Surg. .
No abstract available

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Conflict of interest statement

The authors report no conflicts of interest.

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References

    1. Chowdhury AH, Adiamah A, Kushairi A, et al. Perioperative probiotics or synbiotics in adults undergoing elective abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. Ann Surg 2019; doi: 10.1097/SLA.0000000000003581. [Epub ahead of print]. - DOI
    1. Chowdhury A, Varadhan K, Neal K, et al. Perioperative prebiotics, probiotics or synbiotics for elective abdominal surgery in adults. Cochrane Database Syst Rev 2011; https://www.cochranelibrary.com/cdsrhttps://www.cochranelibrary.com/cdsr doi/10.1002/14651858.CD009246/full. - DOI
    1. Wu X-D, Liu M-M, Liang X, et al. Effects of perioperative supplementation with pro-/synbiotics on clinical outcomes in surgical patients: a meta-analysis with trial sequential analysis of randomized controlled trials. Clin Nutr 2018; 37:505–515.
    1. Zhang Z, Xu X, Ni H. Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study. Crit Care 2013; 17:R2.
    1. Thorlund K, Imberger G, Walsh M, et al. The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis—a simulation study. PLoS One 2011; 6:e25491.

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