Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan;99(1):e18612.
doi: 10.1097/MD.0000000000018612.

Uterus transplant graft's arterial atherosclerotic remodeling veracity

Robert Novotny  1 , Jaroslav Chlupac  1   2 , Jakub Kristek  1   2 , Jan Pit'ha  3 , Roman Chmel  4 , Eva Sticova  5 , Libor Janousek  1 , Jiri Fronek  1   2
Affiliations

Uterus transplant graft's arterial atherosclerotic remodeling veracity

Robert Novotny et al. Medicine (Baltimore). 2020 Jan.

Abstract

Background: Uterus transplantation is a complex, multi-step experimental procedure used for the treatment of uterus absence or uterus anomaly that prevents embryo implantation or pregnancy completion.

Method: To date, only 51 uterus transplants worldwide had been performed. When simplified, it is vascularized composite allograft transplantation. While it is still an experimental procedure with encouraging results for the future, there are still many issues that have to be clarified. The most serious complications of uterus transplantation are graft rejection or grafts vascular failure.

Results: So far, no reference to the atherosclerotic arterial infiltration of the uterus arteries was suggested and studied as one of the main causes of graft's failure.

Conclusion: In this review we summarized current knowledge and possible role of uterus arterial damage, including atherosclerotic changes on the graft's survival.

PubMed Disclaimer

Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Uterine artery: Cross-section of an artery with circular fibro-intimal thickening of the wall narrowing the arterial lumen. (A) Hematoxilin and eosin, (B), van Gieson and Elastin. Orig. magnification ×40.
See this image and copyright information in PMC

References

    1. Del Priore G, Gudipudi DK. Promise of uterine transplant--myth or a reality? Maturitas 2014;77:20–3. - PubMed
    1. Johannesson L, Järvholm S. Uterus transplantation: current progress and future prospects. Int J Womens Health 2016;8:43–51. - PMC - PubMed
    1. Fageeh W, Raffa H, Jabbad H, et al. Transplantation of the human uterus. Int J Gynaecol Obstet 2002;76:245–51. - PubMed
    1. Favre-Inhofer A, Rafii A, Carbonnel M, et al. Uterine transplantation: review in human research. Gynecol Obstet Hum Reprod 2018;47:213–21. - PubMed
    1. Testa G, Koon EC, Johannesson L, et al. Living donor uterus transplantation:a single center's observations and lessons learned from early setbacks to technical success. Am J Transplant 2017;17:2901–10. - PubMed

Publication types