Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb;69(2):191-202.
doi: 10.1007/s00011-019-01307-y. Epub 2020 Jan 2.

Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators

Gyeong Im Yu  1 , Dae Kyu Song  2 , Dong Hoon Shin  3
Affiliations

Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators

Gyeong Im Yu et al. Inflamm Res. 2020 Feb.

Abstract

Objectives: Obesity is attributable to high free fatty acids, ER stress, oxidative stress and inflammation. The expression of IL-33, IL-1RL1 and IL-1RAP gene was observed in human visceral white fats, pre-adipocytes and adipocytes. The aim of this study was to determine whether IL1RAP and IL1RL1 gene variants were associated with obesity and inflammation mediators.

Methods: 3 SNPs of IL1RAP (rs9990107, rs3836449 and rs9290936) and 11 SNPs of IL1RL1 (rs3771180, rs13431828, rs3214363, rs1420101, rs12905, rs3771175, rs3821204, rs12712142, rs10204137, rs4988958, and rs10206753) were genotyped for 175 obesity (BMI ≥ 25) and 358 non-obesity (BMI < 25.0) subjects. The genotype of SNPs was determined by the Axiom Genome-Wide Human Assay.

Results: The allele and genotype frequencies of 2 SNPs in the IL1RAP gene (rs9990107 and rs3836449) and 11 SNPs in the IL1RL1 gene (rs3771180, rs13431828, rs3214363, rs1420101, rs12905, rs3771175, rs3821204, rs12712142, rs10204137, rs4988958 and rs10206753) were significantly associated between the obesity and non-obesity groups. The two haplotypes (GCTTATGAATT and TT-CGACCGCC) in block1 were associated with obesity. In the non-obesity group, genotype frequencies of rs3771180, rs13431828, rs3214363, rs10204137, rs4988958 and rs10206753 SNPs of IL1RL1 showed significant differences in the dominant models in lymphatic cell percentage. The genotype frequencies of rs1420101, rs21905, rs3821024 and rs12712142 SNPs of IL1RL1 showed significant differences in the dominant models in eosinophil percentage.

Conclusions: Our results suggest that IL1RAP and IL1RL1 gene polymorphisms may be associated with obesity and inflammation mediators.

Keywords: IL1RAP; IL1RL1; Inflammation; Obesity; Polymorphisms.

PubMed Disclaimer

References

    1. World Health Organization: Obesity and overweight. World Health Organization Media centre [Serial online]. 2018. https://www.who.int/mediacentre/factsheets/fs311/en/ .
    1. Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33:673–89. - DOI
    1. Korea Centers for Disease Control and Prevention: Korea Health Statistics 2016. Korea National Health and Nutrition Examination Survey (KNHANES VII-1). Seoul: Korea Centers for Disease Control and Prevention; 2017.
    1. Choi J, Park S, Kwon TK, Sohn SI, et al. Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis. Int J Obes (Lond). 2017;41:1702–9. - DOI
    1. Boon MR, Bakker LE, van der Linden RA, et al. High prevalence of cardiovascular disease in South Asians: central role for brown adipose tissue? Crit Rev Clin Lab Sci. 2015;8:1–8.

Substances

LinkOut - more resources