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Review
. 2020 Apr;34(2):117-122.
doi: 10.1007/s00482-019-00438-9.

[Cannabidiol in cancer treatment]

[Article in German]
Rudolf Likar  1 , Markus Köstenberger  2 , Gerhard Nahler  3
Affiliations
Review

[Cannabidiol in cancer treatment]

[Article in German]
Rudolf Likar et al. Schmerz. 2020 Apr.

Abstract
in English, German

Background: Cannabis was used for cancer patients as early as about 2500 years ago. Experimental studies demonstrated tumor-inhibiting activities of various cannabinoids more than 40 years ago. In view of the status of tetrahydrocannabinol (THC) as a regulated substance, non-psychotomimetic cannabidiol (CBD) is of particular importance.

Objectives: Efficacy of pure CBD in various animal models as well as initial results (case reports) from patients.

Methods: Review of the literature on animal experiments and observations in humans.

Results: Preclinical studies, particularly recent ones, including numerous animal models of tumors, unanimously suggest the therapeutic efficacy of CBD. In isolated combination studies, synergistic effects were generally observed. In addition, CBD may potentially play a role in the palliative care of patients, especially concerning symptoms such as pain, insomnia, anxiety, and depression. Further human studies are warranted.

Zusammenfassung: HINTERGRUND: Cannabis wurde bereits vor ca. 2500 Jahren bei Krebspatienten verwendet. Experimentelle Untersuchungen zeigten schon vor mehr als 40 Jahren eine tumorinhibierende Aktivität verschiedener Cannabinoide. In Anbetracht der Stellung von THC als Suchtgift kommt dem nichtpsychotomimetischen CBD eine besondere Bedeutung zu.

Fragestellung: Tumorwirksamkeit von reinem CBD in verschiedenen Tiermodellen sowie erste Ergebnisse (Fallberichte) an Patienten.

Material, methode: Übersicht der Literatur zu Tierstudien und Fallberichte mit CBD ERGEBNISSE: Präklinische Untersuchungen insbesondere während der letzten Jahre, darunter an zahlreichen Tumormodellen am Tier, weisen unisono auf eine therapeutische Wirksamkeit von CBD hin. In vereinzelt durchgeführten Kombinationsstudien zeigten sich in der Regel synergistische Effekte. Darüber hinaus kann CBD möglicherweise in der palliativmedizinischen Versorgung von Patienten insbesondere bei Symptomen wie Schmerzen, Schlaflosigkeit, Angstzuständen und Depression eine Rolle spielen. Weitergehende Humanstudien wären wünschenswert.

Keywords: Cancer; Cannabidiol (CBD); Cannabinoids; Malignant disease; Tumors.

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References

Literatur

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    1. Aviello G, Romano B, Borrelli F, Capasso R, Gallo L, Piscitelli F et al (2012) Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. J Mol Med 90(8):925–934 - PubMed - DOI
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    1. Chavez T (2019) New British study on CBD and pediatric tumors. https://cashcbdoil.com/2019/04/21/new-british-study-on-cbd-and-pediatric... . Zugegriffen: 07.09.2019

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