Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr 15;201(8):1002-1006.
doi: 10.1164/rccm.201911-2127LE.

Human Fetal Lungs Harbor a Microbiome Signature

Affiliations

Human Fetal Lungs Harbor a Microbiome Signature

Denise Al Alam et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
(A) Microbiome analysis of fetal lung, placenta, and small intestine conducted at Singapore. (B) True taxa versus potential contaminants.
Figure 2.
Figure 2.
(A) Matched microbiome profiles of lung (L), placenta (P), and intestines (I) from the same patients. Lung microbiome profile of triplets (LLL) and twins (LL). (B) Shared microbiota in fetal lungs and placentas. (C) Principal coordinate plot showing the β diversity of the fetal and placental microbiomes. PCoA = principal coordinates analysis.

Comment in

References

    1. Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6:237ra65. - PMC - PubMed
    1. Willyard C. Could baby’s first bacteria take root before birth? Nature. 2018;553:264–266. - PubMed
    1. Younge N, McCann JR, Ballard J, Plunkett C, Akhtar S, Araújo-Pérez F, et al. Fetal exposure to the maternal microbiota in humans and mice. JCI Insight. 2019;4:127806. - PMC - PubMed
    1. de Goffau MC, Lager S, Sovio U, Gaccioli F, Cook E, Peacock SJ, et al. Human placenta has no microbiome but can contain potential pathogens. Nature. 2019;572:329–334. - PMC - PubMed
    1. Lal CV, Travers C, Aghai ZH, Eipers P, Jilling T, Halloran B, et al. The airway microbiome at birth. Sci Rep. 2016;6:31023. - PMC - PubMed

Publication types

Substances