The challenge of quantifying and managing pharmacokinetic variability of beta-lactams in the critically ill

Affiliations

¹ Ann Arbor Pharmacometrics Group, Ann Arbor, MI, USA.
² Department of Pharmacy, Sunshine Coast University Hospital, Brisbane, Queensland, Australia; University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia.
³ University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30029 Nîmes, France. Electronic address: j.roberts2@uq.edu.au.

Editorial

Ryan L Crass et al. Anaesth Crit Care Pain Med. 2020 Feb.

. 2020 Feb;39(1):27-29.

doi: 10.1016/j.accpm.2019.12.008. Epub 2019 Dec 31.

¹ Ann Arbor Pharmacometrics Group, Ann Arbor, MI, USA.
² Department of Pharmacy, Sunshine Coast University Hospital, Brisbane, Queensland, Australia; University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia.
³ University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, Queensland, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30029 Nîmes, France. Electronic address: j.roberts2@uq.edu.au.

No abstract available

Keywords: Intensive care; Nomogram; Sepsis; Therapeutic drug monitoring.

Comment on

Pharmacokinetic variability of beta-lactams in critically ill patients: A narrative review.
Boidin C, Moshiri P, Dahyot-Fizelier C, Goutelle S, Lefeuvre S. Boidin C, et al. Anaesth Crit Care Pain Med. 2020 Feb;39(1):87-109. doi: 10.1016/j.accpm.2019.07.016. Epub 2019 Sep 9. Anaesth Crit Care Pain Med. 2020. PMID: 31513935 Review.