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Review
. 2020 Jan 30;41(1):176-183.
doi: 10.1093/jbcr/irz148.

Guidelines for Thrombolytic Therapy for Frostbite

Sean Hickey  1 , Amy Whitson  2 , Larry Jones  2 , Lucy Wibbenmeyer  3 , Colleen Ryan  4 , Ryan Fey  5 , Jeffrey Litt  6 , Renata Fabia  7 , Lee Cancio  8 , William Mohr  9   10 , John Twomey  11 , Anne Wagner  12 , Amalia Cochran  2 , J Kevin Bailey  13
Affiliations
Review

Guidelines for Thrombolytic Therapy for Frostbite

Sean Hickey et al. J Burn Care Res. .

Abstract

The data are insufficient to support standardized treatment of all patients with frostbite with thrombolytic therapy. The following guidelines, however, should be applied to all patients with cyanosis persisting proximal to the distal phalanx (Grade 3 or 4 frostbite injury) and demonstrated loss of perfusion at or proximal to the middle phalanx immediately after rewarming.

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