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. 2020 Jan 3;15(1):e0227359.
doi: 10.1371/journal.pone.0227359. eCollection 2020.

Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia

Beshir Bedru Nasir  1 , Alemseged Beyene Berha  1 , Meron Awraris Gebrewold  2 , Yared Mamushet Yifru  2 , Ephrem Engidawork  1 , Minyahil Alebachew Woldu  1
Affiliations

Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia

Beshir Bedru Nasir et al. PLoS One. .

Abstract

Objective: Epilepsy management especially in developing country is challenging. Seizures recurrence can be caused by both drug and non-drug related problems such as inadequate antiepileptic regimens, adverse drug reaction and poor adherence. Patient treatment satisfaction also affects the treatment out comes by improving medication adherence. This study aimed to assess drug therapy problems (DTPs) and treatment satisfaction among ambulatory epileptic patients at Tikur Anbessa Specialized Hospital.

Methods: A prospective cross-sectional study was conducted on 291 epileptic patients. Data was collected through patient interview and medical charts review. DTPs were identified based on the standard treatment guidelines and Micromedex® was used as drug interaction checker. Cipolle DTPs classification was used to classify the DTPs and Treatment Satisfaction with Medicine Questionnaire (SATMED-Q) was used to assess treatment satisfaction. Binary logistic regressions were utilized to identify the associated factors.

Results: Phenobarbital 195 (67%) and phenytoin 97 (33.3%) were the most frequently prescribed antiepileptic medications as monotherapy or combination therapy. Only 54 (18.6%) of the study participants had controlled seizure. DTP was found in 205(70.4%) of the study participants. From 352 DTPs identified, adverse drug reaction 146 (41.5%) was the leading DTPs followed by ineffective drugs 98 (27.8%) drug interaction 45 (12.8%) and inappropriate dose 42(11.9%). Headache, depression and epigastric pain were frequently reported adverse drug reaction. Among the study participants 167 (57.3%) were adherent to their medications. The number of medications taken by the patients had significant association with occurrence of DTPs, whereas source of medication and seizure free periods were found to have significant association with poor adherence. The global patient satisfaction was (67.4%) and lower satisfaction rate was found with regard to impact on daily activities (62.0%), treatment effectiveness (64.7%) and medical care (65.9%).

Conclusion: Prevalence of DTPs among ambulatory epileptic patients was high and about half of the patients were nona-dherent for their medication. The overall treatment satisfaction of the patients was suboptimal.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Type of drugs involved in drug interaction and their frequency.
See this image and copyright information in PMC

References

    1. Fisher RS, Boas WvE, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005, 46(4):470–472. 10.1111/j.0013-9580.2005.66104.x - DOI - PubMed
    1. Kerr M, Scheepers M, Arvio M, Beavis J, Brandt C, Brown S, et al. Consensus guidelines into the management of epilepsy in adults with an intellectual disability. Journal of Intellectual Disability Research 2009, 53(8):687–694. 10.1111/j.1365-2788.2009.01182.x - DOI - PubMed
    1. Rout SK, Kar DM. A review on antiepileptic agents, current research and Future prospectus on conventional and traditional drugs. Int J Pharm Sci Rev Res 2010, 3(2):19–23.
    1. Henry TR, Conway J. Antiepilepsy drugs: mechanisms of action and pharmacokinetics. Epilepsy Board Rev Man 2012, 1(5):1–11.
    1. Scott RA, Lhatoo SD, Sander JW. The treatment of epilepsy in developing countries: where do we go from here? Bulletin of the World Health Organization 2001, 79(4):344–351. - PMC - PubMed

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