Physical Activity and Breast Cancer: Focusing on High-Risk Subgroups and Putting Recommendations in Context
- PMID: 31900281
- PMCID: PMC7456185
- DOI: 10.1158/0008-5472.CAN-19-3350
Physical Activity and Breast Cancer: Focusing on High-Risk Subgroups and Putting Recommendations in Context
Abstract
While it is well-established that physical activity is associated with a decreased risk of breast cancer, most studies have been conducted in populations at an average underlying breast cancer risk. In this issue of Cancer Research, Kehm and colleagues present compelling evidence that adulthood physical activity is beneficial across the risk spectrum, including among women with BRCA1 and BRCA2 mutations. These findings are significant because women who are at a higher baseline risk are not engaging in sufficient physical activity to meet current guidelines but may be more motivated to do so knowing that they, like women in the general population, may benefit.See related article by Kehm et al., p. 116.
©2020 American Association for Cancer Research.
Comment in
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Recreational Physical Activity Is Associated with Reduced Breast Cancer Risk in Adult Women at High Risk for Breast Cancer: A Cohort Study of Women Selected for Familial and Genetic Risk.Cancer Res. 2020 Jan 1;80(1):116-125. doi: 10.1158/0008-5472.CAN-19-1847. Epub 2019 Oct 2. Cancer Res. 2020. PMID: 31578201 Free PMC article.
Comment on
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Recreational Physical Activity Is Associated with Reduced Breast Cancer Risk in Adult Women at High Risk for Breast Cancer: A Cohort Study of Women Selected for Familial and Genetic Risk.Cancer Res. 2020 Jan 1;80(1):116-125. doi: 10.1158/0008-5472.CAN-19-1847. Epub 2019 Oct 2. Cancer Res. 2020. PMID: 31578201 Free PMC article.
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- Neilson HK, Farris MS, Stone CR, Vaska MM, Brenner DR, Friedenreich CM. Moderate-vigorous recreational physical activity and breast cancer risk, stratified by menopause status: a systematic review and meta-analysis. Menopause 2017;24(3):322–344. - PubMed
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- Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 2001;358(9291):1389–99. - PubMed
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- Kehm RD, Genkinger JM, MacInnis RJ, John EM, Phillips K-A, Dite GS, Milne RL, Zeinomar N, Liao Y, Knight JA, Southey MC, Chung WK, Giles GG, McLachlan S-A, Whitaker KD, Friedlander M, Weideman PC, Glendon G, Nesci S, Andrulis IL, Buys SS, Daly MB, Hopper JL, Terry MB. Recreational physical activity is associated with reduced breast cancer risk in adult women at high risk for breast cancer: a cohort study of women selected for familial and genetic risk. Cancer Research 2019:canres.18472019. - PMC - PubMed
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