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Comment
. 2020 Mar;45(3):179-182.
doi: 10.1016/j.tibs.2019.12.004. Epub 2019 Dec 31.

Histone Lactylation: A New Role for Glucose Metabolism

Maria V Liberti  1 , Jason W Locasale  2
Affiliations
Comment

Histone Lactylation: A New Role for Glucose Metabolism

Maria V Liberti et al. Trends Biochem Sci. 2020 Mar.

Abstract

Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study by Zhang et al. establishes a novel function for lactate whereby it is utilized in a new histone modification, histone lysine lactylation, to regulate gene expression in macrophages.

Keywords: Warburg effect; histone lactylation; lactate; macrophage polarization.

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  • Metabolic regulation of gene expression by histone lactylation.
    Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y. Zhang D, et al. Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1. Epub 2019 Oct 23. Nature. 2019. PMID: 31645732 Free PMC article.

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