Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan:51:102590.
doi: 10.1016/j.ebiom.2019.11.051. Epub 2020 Jan 3.

Role of gut microbiota in type 2 diabetes pathophysiology

Manoj Gurung  1 , Zhipeng Li  1 , Hannah You  1 , Richard Rodrigues  2 , Donald B Jump  3 , Andrey Morgun  4 , Natalia Shulzhenko  5
Affiliations
Review

Role of gut microbiota in type 2 diabetes pathophysiology

Manoj Gurung et al. EBioMedicine. 2020 Jan.

Abstract

A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D.

Keywords: 16S rRNA; Insulin resistance; Metagenomics; Microbiota; Type 2 diabetes.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Microbial genera most frequently found to be associated with T2D. Number of studies reporting one of the indicated genera in association with T2D (without treatment), and including anti-diabetic therapy (All) in addition to the largest human study by He et al., 2018 .
Fig. 2
Fig. 2
Literature-based network analysis of potential effects on metabolism of bacterial taxa consistently found in association with human T2D (shown in Fig. 1). References corresponding to each edge can be found in the text.
See this image and copyright information in PMC

References

    1. He Y. Regional variation limits applications of healthy gut microbiome reference ranges and disease models. Nat Med. 2018;24(10):1532–1535. - PubMed
    1. Gao R. Dysbiosis signatures of gut microbiota along the sequence from healthy, young patients to those with overweight and obesity. Obesity (Silver Spring) 2018;26(2):351–361. - PubMed
    1. Candela M. Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet. Br J Nutr. 2016;116(1):80–93. - PMC - PubMed
    1. Sedighi M. Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals. Microb Pathog. 2017;111:362–369. - PubMed
    1. Wu X. Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol. 2010;61(1):69–78. - PubMed

MeSH terms