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. 2019:96:418-435.
doi: 10.15227/orgsyn.096.0418. Epub 2019 Oct 7.

a nti-1,2,2,3,4,4-Hexamethylphosphetane 1-oxide

Trevor V Nykaza  1 , Julian C Cooper  1 , Alexander T Radosevich  1
Affiliations

a nti-1,2,2,3,4,4-Hexamethylphosphetane 1-oxide

Trevor V Nykaza et al. Organic Synth. 2019.

Abstract

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Figures

Figure 1.
Figure 1.
A) Reaction set-up/aluminum chloride stirring in CH2Cl2 at 0 °C. B) Five min after the addition of 2,4,4-trimethyl-2-pentene, white precipitate is observed. C) Quench set-up. (Photos provided by the checkers)
Figure 2.
Figure 2.
Recrystallized phosphetane oxide 1. Crystals are thick needles and tend to clump together during the recrystallization. (Photo provided by the submitters)
Figure 3.
Figure 3.
A) Reaction set-up/reaction mixture heating at 35 °C after Grignard addition with precipitate formation. B) Reaction mixture after quenching with saturated ammonium chloride. (Photo provided by the checkers)
Figure 4.
Figure 4.
Product 2 after Et2O slurry and vacuum filtration. (Photo provided by the submitters)
Scheme 1.
Scheme 1.
A general representation of PIII/PV=O redox cycling in which starting material A is converted to product B and generalized reductant [R] is employed
See this image and copyright information in PMC

References

    1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, radosevich@mit.edu We thank NIH NIGMS (GM114547) and MIT for funding support. ORCID (ATR): 0000-0002-5373-7343
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